Apremilast and Tacrolimus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Apremilast (apremilast) and Tacrolimus (tacrolimus). Common drug interactions include drug ineffective among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Apremilast and Tacrolimus. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Apremilast?

Apremilast has active ingredients of apremilast. eHealthMe is studying from 4,162 Apremilast users. Check the latest studies of Apremilast.

What is Tacrolimus?

Tacrolimus has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 116,160 Tacrolimus users. Check the latest studies of Tacrolimus.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

58 people who take Apremilast and Tacrolimus together, and have interactions are studied.

Apremilast and Tacrolimus drug interactions.

What are the common drug interactions of Apremilast and Tacrolimus, by gender? *:

female:

Drug ineffective
Pruritus (severe itching of the skin)
Type 1 diabetes mellitus
Erythema multiforme (a type of hypersensitivity reaction)
Drug dependence
Lichen planus (an inflammatory skin condition, characterized by an itchy, non-infectious rash)
Maternal exposure during pregnancy (use of substance during pregnancy)
Nausea (feeling of having an urge to vomit)
Abortion (termination of pregnancy)
Abortion induced (medically referred abortion)

male:

Drug ineffective
Psoriasis (immune-mediated disease that affects the skin)
Hepatotoxicity (chemical-driven liver damage)
Herpes zoster
Lentigo (a small pigmented spot on the skin with a clearly-defined edge, surrounded by normal-appearing skin)
Macule (a discoloured spot on the skin)
Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))
Myopathy (a muscular disease in which the muscle fibres do not function)
Papule
Pruritus (severe itching of the skin)

What are the common drug interactions of Apremilast and Tacrolimus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cushing's syndrome (obesity, a rounded face, increased fat)
Disease progression
Gait disturbance
Obesity (having too much body fat)
Pain
Drug ineffective
Psoriasis (immune-mediated disease that affects the skin)
Skin exfoliation (removal of the oldest dead skin cells)

20-29:

Drug ineffective
Erythema multiforme (a type of hypersensitivity reaction)
Maternal exposure during pregnancy (use of substance during pregnancy)
Normal newborn
Pruritus (severe itching of the skin)
Psoriasis (immune-mediated disease that affects the skin)

30-39:

n/a

40-49:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Drug ineffective
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)
Injection site haemorrhage (bleeding from injection site)
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Scratch
Stress

50-59:

Drug ineffective
Type 1 diabetes mellitus
Pneumonia
Pruritus (severe itching of the skin)
Erythema multiforme (a type of hypersensitivity reaction)
Diarrhoea
Nausea (feeling of having an urge to vomit)
Disease progression
Adverse event
Arthralgia (joint pain)

60+:

Drug ineffective
Skin infection
Psoriasis (immune-mediated disease that affects the skin)
Sepsis (a severe blood infection that can lead to organ failure and death)
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Cutaneous sarcoidosis (a multisystem disease with skin lesion)
Dermatitis infected (inflammation of the skin due to infection)
Disease progression
Pain
Cellulitis (infection under the skin)

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 11 people, 18.97%
Erythema Multiforme (a type of hypersensitivity reaction): 8 people, 13.79%
Benign Familial Pemphigus (acute or chronic skin diseases characterized by groups of itching blisters): 8 people, 13.79%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 5 people, 8.62%
Lichen Planus (an inflammatory skin condition, characterized by an itchy, non-infectious rash): 4 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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