Apresoline and Procardia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Apresoline (hydralazine hydrochloride) and Procardia (nifedipine). Common drug interactions include cough among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Apresoline and Procardia. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Apresoline?

Apresoline has active ingredients of hydralazine hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 2,475 Apresoline users. Check the latest studies of Apresoline.

What is Procardia?

Procardia has active ingredients of nifedipine. It is often used in high blood pressure. eHealthMe is studying from 15,151 Procardia users. Check the latest studies of Procardia.

On Jul, 19, 2026

72 people who take Apresoline and Procardia together, and have interactions are studied.

Apresoline and Procardia drug interactions.

What are the common drug interactions of Apresoline and Procardia, by gender? *:

female:

Cough
Diarrhoea
Malaise (a feeling of general discomfort or uneasiness)
Weight increased
Abdominal distension
Anaemia (lack of blood)
Cardiac murmur (an heart sound in valve abnormality)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Emotional distress

male:

Cardiac failure congestive
Renal failure (kidney dysfunction)
Pyrexia (fever)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Bradycardia (abnormally slow heart action)
Cardioactive drug level increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Diarrhoea
Fall

What are the common drug interactions of Apresoline and Procardia, by age (0-1 to 60+)? *:

0-1:

Cardiac murmur (an heart sound in valve abnormality)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Premature baby
Tricuspid valve incompetence (inefficient heart valve)
Pneumonia

2-9:

Cerebral hypoperfusion (a condition in which the brain doesn't get enough blood)
Hydrocephalus (water on the brain)
Abdominal distension
Cerebral artery stenosis (hardening of brain blood vessels)
Delayed recovery from anaesthesia
Ejection fraction decreased (systolic heart failure)
Encephalitis (inflammation of the brain)
Hypokalaemia (low potassium)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Lipase increased

10-19:

Anaemia (lack of blood)

20-29:

Arthralgia (joint pain)
Back pain
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Fall
Joint lock
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Peroneal nerve palsy
Vascular calcification (deposits of calcium in the blood vessels)

30-39:

Atelectasis (partial or complete collapse of the lung)
Bicytopenia (two parameters from the full blood count are low, the term bicytopenia can be used)
Blood pressure decreased
Chest pain
Extrasystoles
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypertensive crisis
Hypertensive emergency
Hypokalaemia (low potassium)

40-49:

Renal failure (kidney dysfunction)
Depression
Renal injury (kidney injury)
Chronic kidney disease
Anxiety
Emotional distress
Fear
Injury
Multi-organ failure (multisystem organ failure)
Nephrogenic anaemia (anaemia due to kidney disease)

50-59:

Renal failure (kidney dysfunction)
Vomiting
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Back pain
Bradycardia (abnormally slow heart action)
Cardiac failure congestive
Cerebral artery occlusion (blockage of blood vessel of brain by fat or clot)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Coronary arterial stent insertion
Flushing (the warm, red condition of human skin)

60+:

Cardiac failure congestive
Dyspnoea (difficult or laboured respiration)
Pulmonary oedema (fluid accumulation in the lungs)
Chronic kidney disease
Nausea (feeling of having an urge to vomit)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardioactive drug level increased
Cerebrovascular disorder (disease of brain)
Chest pain
Hyperkalaemia (damage to or disease of the kidney)

What are the existing conditions these people have? *

Pain: 7 people, 9.72%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 9.72%
Depression: 6 people, 8.33%
Nausea (feeling of having an urge to vomit): 5 people, 6.94%
Oedema Peripheral (superficial swelling): 4 people, 5.56%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 4 people, 5.56%
Diabetes: 4 people, 5.56%
Constipation: 4 people, 5.56%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 5.56%
Asthma: 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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