Apriso and Prolia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Apriso (mesalamine) and Prolia (denosumab). Common drug interactions include alopecia among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Apriso and Prolia. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Apriso?

Apriso has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 3,439 Apriso users. Check the latest studies of Apriso.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,388 Prolia users. Check the latest studies of Prolia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

13 people who take Apriso and Prolia together, and have interactions are studied.

What are the common drug interactions of Apriso and Prolia, by gender? *:

female:

Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Decreased immune responsiveness
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hordeolum (small collection of pus (abscess) on the eyelid)
Nodule (a growth of abnormal tissue)
Oral herpes (viral infection of mouth)
Rash
Rash papular (redness with papule)

male:

Diarrhoea
Emotional distress
Psoriasis (immune-mediated disease that affects the skin)
Respiratory failure (inadequate gas exchange by the respiratory system)
Speech disorder
Eosinophil count increased
Fracture
Haematochezia (passage of stools containing blood)
Headache (pain in head)
Hypotonia (low muscle tone)

What are the common drug interactions of Apriso and Prolia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Emotional distress
Fracture
Osteopenia (a condition where bone mineral density is lower than normal)
Pain

60+:

Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Tumour marker increased
Vaginal infection
Asthenia (weakness)
Back disorder
Diarrhoea
Eosinophil count increased
Fall
Haematochezia (passage of stools containing blood)

What are the existing conditions these people have? *

High Blood Cholesterol: 3 people, 23.08%
High Blood Pressure: 3 people, 23.08%
Breast Cancer Metastatic: 2 people, 15.38%
Colitis (inflammation of colon): 2 people, 15.38%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 15.38%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 2 people, 15.38%
Breast Cancer Female: 2 people, 15.38%
Bacterial Infection: 1 person, 7.69%
B-Cell Small Lymphocytic Lymphoma (blood cancer affecting b cells): 1 person, 7.69%
Asthma: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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