Arava and Apixaban drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arava (leflunomide) and Apixaban (apixaban). Common drug interactions include drug ineffective among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Arava and Apixaban. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

What is Apixaban?

Apixaban has active ingredients of apixaban. It is often used in blood clots. eHealthMe is studying from 60,351 Apixaban users. Check the latest studies of Apixaban.

On Jul, 25, 2026

38 people who take Arava and Apixaban together, and have interactions are studied.

What are the common drug interactions of Arava and Apixaban, by gender? *:

female:

Drug ineffective
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Thrombocytopenia (decrease of platelets in blood)
Anaemia (lack of blood)
Arthralgia (joint pain)
Blood creatinine increased
Cough
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Discomfort

male:

Diarrhoea
Drug ineffective
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Death
Neoplasm malignant (cancer tumour)
Neutropenia (an abnormally low number of neutrophils)
Pneumonia
Pulmonary mass
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Thrombocytopenia (decrease of platelets in blood)

What are the common drug interactions of Arava and Apixaban, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Plantar fasciitis (painful inflammatory process of the plantar fascia)

60+:

Diarrhoea
Drug ineffective
Cough
Dehydration (dryness resulting from the removal of water)
Discomfort
Drug hypersensitivity
Fatigue (feeling of tiredness)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Interstitial lung disease
Joint stiffness

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 7.89%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 5.26%
Dyslipidaemia (abnormal amount of lipids): 2 people, 5.26%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Arava and Apixaban?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously