Arava and Atarax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arava (leflunomide) and Atarax (hydroxyzine hydrochloride). Common drug interactions include disturbance in attention among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Arava and Atarax. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

What is Atarax?

Atarax has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 23,553 Atarax users. Check the latest studies of Atarax.

On Jul, 12, 2026

92 people who take Arava and Atarax together, and have interactions are studied.

What are the common drug interactions of Arava and Atarax, by gender? *:

female:

Disturbance in attention
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Fibromyalgia (a long-term condition which causes pain all over the body)
General physical health deterioration (weak health status)
Increased appetite
Muscle spasms (muscle contraction)
Nervousness
Obesity (having too much body fat)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)

male:

Anaemia (lack of blood)
Asthenia (weakness)
Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Laryngeal discomfort
Lip oedema (swelling of lip)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Multi-organ failure (multisystem organ failure)
Nausea (feeling of having an urge to vomit)
Ocular icterus (presence of jaundice seen in the sclera of the eye)
Pneumonia

What are the common drug interactions of Arava and Atarax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Face oedema (swelling of face)
Laryngeal discomfort
Lip oedema (swelling of lip)
Tongue oedema (swelling of tongue)
Pneumonia bacterial (pneumonia associated with bacterial infection)

30-39:

Antinuclear antibody positive
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Juvenile arthritis (arthritis-related condition that develops in children or teenagers)
Skin hyperpigmentation (disorders affect the colour of your skin)
Abdominal pain
Oropharyngeal pain

40-49:

Pyrexia (fever)
Nausea (feeling of having an urge to vomit)
Weight decreased
Psoriasis (immune-mediated disease that affects the skin)
Acne (skin problems that cause pimples)
General physical health deterioration (weak health status)
Migraine (headache)
Abdominal discomfort
Blood pressure systolic increased
Chest pain

50-59:

Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Viral infection
Vomiting
Drug ineffective
Nausea (feeling of having an urge to vomit)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Hepatitis (inflammation of the liver)
Dyspnoea (difficult or laboured respiration)
Hepatocellular injury (liver injury)

60+:

Diarrhoea
Gastric ulcer (stomach ulcer)
Hepatitis acute
Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Hepatocellular damage (liver damage)
Injection site haematoma (localized swelling filled with blood at injection site)
Injection site pain
Multi-organ failure (multisystem organ failure)
Ocular icterus (presence of jaundice seen in the sclera of the eye)
Protein total decreased

What are the existing conditions these people have? *

Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 19 people, 20.65%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 18 people, 19.57%
Contrast Media Allergy (reaction associated with the use of intravenous contrast material during radiology): 9 people, 9.78%
Itching: 8 people, 8.70%
High Blood Cholesterol: 8 people, 8.70%
Pain: 7 people, 7.61%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 5 people, 5.43%
Neuropathy Peripheral (surface nerve damage): 5 people, 5.43%
High Blood Pressure: 5 people, 5.43%

* Approximation only. Some reports may have incomplete information.

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