Arava and Didronel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arava (leflunomide) and Didronel (etidronate disodium). Common drug interactions include pulmonary fibrosis among females and acute myocardial infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Arava and Didronel. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

What is Didronel?

Didronel has active ingredients of etidronate disodium. eHealthMe is studying from 1,587 Didronel users. Check the latest studies of Didronel.

On Jul, 18, 2026

40 people who take Arava and Didronel together, and have interactions are studied.

What are the common drug interactions of Arava and Didronel, by gender? *:

female:

Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Peripheral neuropathy (damage to nerves of the peripheral nervous system)
Diarrhoea
Asthenia (weakness)
Duodenal ulcer
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Intestinal perforation (complete penetration of the wall of the intestine)
Large intestinal ulcer
Tuberculosis (a bacterial infection by mycobacterium tuberculosis)

male:

Acute myocardial infarction (acute heart attack)
Diffuse large b-cell lymphoma (cancer of b cells, a type of white blood cell)
Impaired healing
Skin infection
Synovitis (inflammation of the synovial membrane)
Chills (felling of cold)
Dyspepsia (indigestion)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pyrexia (fever)
Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot)

What are the common drug interactions of Arava and Didronel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Colitis (inflammation of colon)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Diarrhoea
Drug ineffective
Ileitis (inflammation of the ileum)
Melanosis (a disorder of pigmentation of the wall of the colon)

50-59:

Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Haemorrhage (bleeding)
Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)
Hypertensive crisis
Loss of consciousness
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pyrexia (fever)
Thrombocytopenia (decrease of platelets in blood)
Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot)
Tonic seizures (all the muscles to suddenly become stiff)

60+:

Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Peripheral neuropathy (damage to nerves of the peripheral nervous system)
Cheilitis (infection of lips)
Cystitis haemorrhagic (blood in the urine and painful voiding)
Diarrhoea
Dyspepsia (indigestion)
Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
Escherichia infection (bacterial infection by escherichia coli)
Lymph node tuberculosis
Neuropathy peripheral (surface nerve damage)

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 3 people, 7.50%
Gastritis (inflammation of stomach): 3 people, 7.50%

* Approximation only. Some reports may have incomplete information.

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