Arava and Klor-con drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arava (leflunomide) and Klor-con (potassium chloride). Common drug interactions include musculoskeletal stiffness among females and arrhythmia among males.

The phase IV clinical study analyzes what interactions people have when they take Arava and Klor-con. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

What is Klor-con?

Klor-con has active ingredients of potassium chloride. It is often used in hypokalemia. eHealthMe is studying from 27,547 Klor-con users. Check the latest studies of Klor-con.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

91 people who take Arava and Klor-con together, and have interactions are studied.

What are the common drug interactions of Arava and Klor-Con, by gender? *:

female:

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain
Cardiac failure congestive
Diarrhoea
Drug ineffective
Arthralgia (joint pain)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

male:

Arrhythmia (irregular heartbeat)
Heart valve incompetence (heart's valves do not work correctly)
Sinusitis (inflammation of sinus)
Skin cancer
Thermal burn (burn by heat)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Cataract cortical (it affects outer part of lens)
Erectile dysfunction
Hypokinesia (decreased bodily movement)
Pain

What are the common drug interactions of Arava and Klor-Con, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Coombs negative haemolytic anaemia
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Chronic kidney disease
Dizziness
Nausea (feeling of having an urge to vomit)
Renal failure (kidney dysfunction)
Vomiting

50-59:

Diverticular perforation (serious gastrointestinal condition in which the intestine's walls are perforated)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Furuncle (infection of the hair follicle)
Gastrointestinal stoma complication (complication of an opening surgically made in digestive tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Incision site infection (infection at incision site)
Ligament sprain (ligament stretched)
Mycobacterium marinum infection (a free-living bacterium, which causes opportunistic infections in humans)
Nodule (a growth of abnormal tissue)
Osteoporosis (bones weak and more likely to break)

60+:

Cardiac failure congestive
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Heart valve incompetence (heart's valves do not work correctly)
Weight decreased
Weight increased
Drug ineffective
Abdominal distension
Arthralgia (joint pain)
Back pain
Decreased appetite

What are the existing conditions these people have? *

Pain: 8 people, 8.79%
High Blood Pressure: 8 people, 8.79%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 7 people, 7.69%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 7.69%
Stress And Anxiety: 6 people, 6.59%
Insomnia (sleeplessness): 5 people, 5.49%
High Blood Cholesterol: 5 people, 5.49%

* Approximation only. Some reports may have incomplete information.

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