Arava and Lotrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arava (leflunomide) and Lotrel (amlodipine besylate; benazepril hydrochloride). Common drug interactions include aphagia among females and amnesia among males.

The phase IV clinical study analyzes what interactions people have when they take Arava and Lotrel. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

What is Lotrel?

Lotrel has active ingredients of amlodipine besylate; benazepril hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 13,571 Lotrel users. Check the latest studies of Lotrel.

On Jul, 10, 2026

51 people who take Arava and Lotrel together, and have interactions are studied.

What are the common drug interactions of Arava and Lotrel, by gender? *:

female:

Aphagia (inability or refusal to swallow)
Body temperature decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Burning sensation
Cataract (clouding of the lens inside the eye)
Chest pain
Coma (state of unconsciousness lasting more than six hours)
Confusional state
Cough
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)

male:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthenia (weakness)
Abdominal pain
Decreased appetite
Drug effect decreased
Gait disturbance
Nasopharyngitis (inflammation of the nasopharynx)
Pain
Pancreatolithiasis (presence of calculi or stones in the pancreas or pancreatic duct)
Pruritus (severe itching of the skin)

What are the common drug interactions of Arava and Lotrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Sinusitis (inflammation of sinus)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tremor (trembling or shaking movements in one or more parts of your body)
Upper respiratory tract infection
Blood uric acid increased
Hepatic enzyme increased
Back pain
Chest pain
Drug effect decreased
Dyspnoea (difficult or laboured respiration)

50-59:

Accident at work
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Infection
Blood glucose decreased
Malaise (a feeling of general discomfort or uneasiness)
Abasia (inability to walk)
Back pain
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Diarrhoea
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

60+:

Pain
Back pain
Head injury
Muscular weakness (muscle weakness)
Swelling
Ankle fracture
Fall
Fatigue (feeling of tiredness)
Sleep disorder
Vision blurred

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 5.88%
Pain: 3 people, 5.88%
Osteoporosis (bones weak and more likely to break): 3 people, 5.88%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 5.88%
Diabetes: 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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