Arava and Phentermine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arava (leflunomide) and Phentermine (phentermine hydrochloride). Common drug interactions include pain among females and adverse drug reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Arava and Phentermine. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

What is Phentermine?

Phentermine has active ingredients of phentermine hydrochloride. It is often used in weight loss. eHealthMe is studying from 19,870 Phentermine users. Check the latest studies of Phentermine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

16 people who take Arava and Phentermine together, and have interactions are studied.

Arava and Phentermine drug interactions.

What are the common drug interactions of Arava and Phentermine, by gender? *:

female:

Pain
Injection site erythema (redness at injection site)
Injection site pruritus (severe itching at injection site)
Pain in extremity
Surgery
Arthralgia (joint pain)
Back pain
Drug ineffective
Infection
Insomnia (sleeplessness)

male:

Adverse drug reaction
Cardiovascular disorder (heart diseases)
Pain

What are the common drug interactions of Arava and Phentermine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

40-49:

n/a

50-59:

Anxiety
Headache (pain in head)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Heart rate increased
Kidney infection
Migraine (headache)
Infusion related reaction
Asthenia (weakness)

60+:

n/a

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 6 people, 37.50%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 6.25%
Pain: 1 person, 6.25%
Migraine (headache): 1 person, 6.25%
Inflammatory Pain: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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