Arava and Rizatriptan benzoate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arava (leflunomide) and Rizatriptan benzoate (rizatriptan benzoate). Common drug interactions include drug ineffective among females.

The phase IV clinical study analyzes what interactions people have when they take Arava and Rizatriptan benzoate. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

What is Rizatriptan benzoate?

Rizatriptan benzoate has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 1,886 Rizatriptan benzoate users. Check the latest studies of Rizatriptan benzoate.



On Jul, 16, 2026

33 people who take Arava and Rizatriptan benzoate together, and have interactions are studied.

Arava and Rizatriptan benzoate drug interactions.

What are the common drug interactions of Arava and Rizatriptan Benzoate, by gender? *:

female:

  1. Drug ineffective
  2. Arthralgia (joint pain)
  3. Hypersensitivity
  4. Infusion related reaction
  5. Neuralgia (pain in one or more nerves)
  6. Oral pruritus (itching in mouth)
  7. Pain
  8. Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
  9. Sinusitis (inflammation of sinus)
  10. Throat irritation

male:

n/a

What are the common drug interactions of Arava and Rizatriptan Benzoate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Drug ineffective
  2. Nausea (feeling of having an urge to vomit)
  3. Vomiting
  4. Anaphylactic reaction (serious allergic reaction)
  5. Ankylosing spondylitis (type of arthritis affecting the spine)
  6. Hypermobility syndrome (abnormalities cause abnormal stress on a joint or many joint)
  7. Vertigo
  8. Abortion spontaneous (naturally occurring miscarriage)
  9. Pregnancy

40-49:

  1. Drug ineffective
  2. Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
  3. Arthralgia (joint pain)
  4. Autoimmune hepatitis
  5. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  6. Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
  7. Dactylitis (dactylitis or sausage digit is inflammation of an entire digit (a finger or toe), and can be painful)
  8. Hepatomegaly (abnormal enlargement of the liver)
  9. Joint stiffness
  10. Joint swelling

50-59:

  1. Allergy to animal
  2. Arthralgia (joint pain)
  3. Oral pruritus (itching in mouth)
  4. Pain
  5. Sinusitis (inflammation of sinus)
  6. Throat irritation
  7. Urticaria (rash of round, red welts on the skin that itch intensely)
  8. Weight fluctuation
  9. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  10. Dizziness

60+:

n/a

What are the existing conditions these people have? *

  1. Herpes Zoster: 14 people, 42.42%
  2. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 11 people, 33.33%
  3. Breakthrough Pain: 2 people, 6.06%
  4. Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 6.06%
  5. Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Arava and Rizatriptan benzoate?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Arava and Rizatriptan benzoate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Arava:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Rizatriptan benzoate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Arava and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Rizatriptan benzoate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on leflunomide and rizatriptan benzoate (the active ingredients of Arava and Rizatriptan benzoate, respectively), and Arava and Rizatriptan benzoate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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