Arava and Rocaltrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arava (leflunomide) and Rocaltrol (calcitriol). Common drug interactions include muscular weakness among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Arava and Rocaltrol. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

What is Rocaltrol?

Rocaltrol has active ingredients of calcitriol. It is often used in hypoparathyroidism. eHealthMe is studying from 7,562 Rocaltrol users. Check the latest studies of Rocaltrol.

On Jul, 11, 2026

54 people who take Arava and Rocaltrol together, and have interactions are studied.

What are the common drug interactions of Arava and Rocaltrol, by gender? *:

female:

Muscular weakness (muscle weakness)
Myalgia (muscle pain)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Neuropathy peripheral (surface nerve damage)
Pain
Pathological fracture (broken bone caused by disease)
Proteinuria (presence of protein in the urine)
Rectal bleeding (bleeding from rectum)
Red blood cell count decreased
Skeletal injury (bone and supporting muscle injury)

male:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Abdominal pain
Abdominal pain upper
Blood bilirubin increased
Blood glucose increased
Breath sounds decreased
Dizziness (excl vertigo)
Duodenal ulcer
Faecal occult blood (blood clot in stool)

What are the common drug interactions of Arava and Rocaltrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Anaemia (lack of blood)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Death
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Ear pain
Gastroenteritis (inflammation of stomach and intestine)
Headache (pain in head)
Hypotension (abnormally low blood pressure)

40-49:

Hyperventilation
Malaise (a feeling of general discomfort or uneasiness)
Pruritus (severe itching of the skin)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Loss of consciousness
Hypertension (high blood pressure)

50-59:

Muscular weakness (muscle weakness)
Myalgia (muscle pain)
Neuropathy peripheral (surface nerve damage)
Abdominal discomfort
Atypical femur fracture
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Dyspepsia (indigestion)
Fall
Femur fracture
Fracture displacement

60+:

Diarrhoea
Nausea (feeling of having an urge to vomit)
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Death
Pyrexia (fever)
Vomiting
Ankle deformity
Cachexia (loss of weight)
Decreased appetite

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 18 people, 33.33%
Pain: 6 people, 11.11%
Stress And Anxiety: 4 people, 7.41%
Radiculopathy (a set of conditions in which one or more nerves is affected and does not work properly): 4 people, 7.41%
Back Pain: 4 people, 7.41%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 7.41%
Hypoaesthesia (reduced sense of touch or sensation): 3 people, 5.56%
Hepatitis (inflammation of the liver): 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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