Arava and Tracleer drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arava (leflunomide) and Tracleer (bosentan). Common drug interactions include sleep apnoea syndrome among females and haemorrhage intracranial among males.

The phase IV clinical study analyzes what interactions people have when they take Arava and Tracleer. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

What is Tracleer?

Tracleer has active ingredients of bosentan. It is often used in primary pulmonary hypertension. eHealthMe is studying from 55,125 Tracleer users. Check the latest studies of Tracleer.

On Jul, 12, 2026

45 people who take Arava and Tracleer together, and have interactions are studied.

What are the common drug interactions of Arava and Tracleer, by gender? *:

female:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Sleep disorder
Spinal fracture (fracture in one of vertebrae)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Thrombosis (formation of a blood clot inside a blood vessel)
Tooth discolouration (a change in colour of teeth)
Upper respiratory tract infection
Ventricular extrasystoles (premature cardiac contraction)
Vomiting
Weakness

male:

Haemorrhage intracranial (bleeding within the skull)
Cough
Respiratory failure (inadequate gas exchange by the respiratory system)
Concomitant disease progression (progress in accompanying disease)
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Blood creatinine increased
Blood urea increased
Cerebral artery embolism (sudden blocking of an artery by a clot or foreign material)
Diarrhoea
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)

What are the common drug interactions of Arava and Tracleer, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Dyspnoea (difficult or laboured respiration)
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
Blood alkaline phosphatase nos increased
Cough
Dental caries
Dry mouth
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)

50-59:

Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Swelling
Ventricular extrasystoles (premature cardiac contraction)
Vomiting
Cough
Pulmonary vascular resistance abnormality
Right ventricular failure (right half of the heart fails to work)
Fatigue (feeling of tiredness)
Concomitant disease progression (progress in accompanying disease)
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)

60+:

Pulmonary hypertension (increase in blood pressure in the lung artery)
Alanine aminotransferase increased
Blood pressure increased
General physical health deterioration (weak health status)
Medical device complication
Nausea (feeling of having an urge to vomit)
Pneumonia
Presyncope
Rash
Back pain

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 15 people, 33.33%
High Blood Pressure: 8 people, 17.78%
Osteoporosis (bones weak and more likely to break): 7 people, 15.56%
Depression: 5 people, 11.11%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 5 people, 11.11%
High Blood Cholesterol: 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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