Arginine and Spiriva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arginine (l - arginine) and Spiriva (tiotropium bromide monohydrate). Common drug interactions include pain among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Arginine and Spiriva. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Arginine?

Arginine has active ingredients of l - arginine. It is often used in erection problems. eHealthMe is studying from 2,612 Arginine users. Check the latest studies of Arginine.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

36 people who take Arginine and Spiriva together, and have interactions are studied.

What are the common drug interactions of Arginine and Spiriva, by gender? *:

female:

Pain
Obesity (having too much body fat)
Lung neoplasm malignant (cancer tumour of lung)
Somnolence (a state of near-sleep, a strong desire for sleep)
Throat irritation
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Lymphoma (cancer that begins in immune system cells)
Oropharyngeal pain
Tongue neoplasm (tumour of tongue)

male:

Diarrhoea
Fatigue (feeling of tiredness)
Dyspnoea exertional (breathlessness or shortness of breath)
Fluid retention (an abnormal accumulation of fluid in the blood)
Fungal infection
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hyperkalaemia (damage to or disease of the kidney)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

What are the common drug interactions of Arginine and Spiriva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Arthralgia (joint pain)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Fungal infection
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)
Hypotension (abnormally low blood pressure)

60+:

Pain
Obesity (having too much body fat)
Fatigue (feeling of tiredness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Deafness bilateral
Drug ineffective
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Ototoxicity (damage to the ear)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tinnitus (a ringing in the ears)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 17 people, 47.22%
Hepatitis C: 3 people, 8.33%
Toothaches (tooth pain): 2 people, 5.56%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 5.56%
High Blood Pressure: 2 people, 5.56%
Headache (pain in head): 2 people, 5.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.56%
Depression: 2 people, 5.56%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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