Aricept and Linzess drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aricept (donepezil hydrochloride) and Linzess (linaclotide). Common drug interactions include dyspnoea among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Aricept and Linzess. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Aricept?

Aricept has active ingredients of donepezil hydrochloride. It is often used in alzheimer's disease. eHealthMe is studying from 24,756 Aricept users. Check the latest studies of Aricept.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

65 people who take Aricept and Linzess together, and have interactions are studied.

What are the common drug interactions of Aricept and Linzess, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Head injury
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypokinesia (decreased bodily movement)
Influenza
Injection site pain
Malaise (a feeling of general discomfort or uneasiness)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Neoplasm (tumour)
Nephrogenic anaemia (anaemia due to kidney disease)

male:

Dyspnoea (difficult or laboured respiration)
Adverse event
Immunosuppression
Injection site haemorrhage (bleeding from injection site)
Nausea (feeling of having an urge to vomit)
Progressive relapsing multiple sclerosis (chronic autoimmune disease of the central nervous system in which gradual destruction of myelin occurs in patches throughout the brain or spinal cord or both)
Somnolence (a state of near-sleep, a strong desire for sleep)
Drug ineffective
Aggression
Agitation (state of anxiety or nervous excitement)

What are the common drug interactions of Aricept and Linzess, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Adverse event
Gastric cancer (stomach cancer)
Immunosuppression
Injection site haemorrhage (bleeding from injection site)
Progressive relapsing multiple sclerosis (chronic autoimmune disease of the central nervous system in which gradual destruction of myelin occurs in patches throughout the brain or spinal cord or both)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

40-49:

Dyspnoea (difficult or laboured respiration)
Fall
Head injury
Pneumonia
Salivary hypersecretion (excess saliva secretion)
Subdural haematoma (blood collects between the skull and the surface of the brain)

50-59:

Actinic keratosis (skin disease due to sun exposure)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bowen's disease (early stage of skin cancer)
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Rash

60+:

Death
Confusional state
Anger
Asthenia (weakness)
Bacteraemia (presence of bacteria in the blood)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness
Exercise tolerance decreased
Gait disturbance
Hallucination (an experience involving the perception of something not present)

What are the existing conditions these people have? *

Parkinson's Disease: 17 people, 26.15%
Hallucinations (sensations that appear real but are created by your mind): 10 people, 15.38%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 12.31%
Delusion (a false belief or opinion): 7 people, 10.77%
Pain: 6 people, 9.23%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 7.69%
High Blood Cholesterol: 5 people, 7.69%
Thyroid Diseases: 4 people, 6.15%
Nausea (feeling of having an urge to vomit): 4 people, 6.15%
Immunodeficiency Common Variable: 4 people, 6.15%

* Approximation only. Some reports may have incomplete information.

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