Arixtra and Dilantin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arixtra (fondaparinux sodium) and Dilantin (phenytoin sodium). Common drug interactions include oedema peripheral among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Arixtra and Dilantin. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Arixtra?

Arixtra has active ingredients of fondaparinux sodium. It is often used in deep venous thrombosis. eHealthMe is studying from 9,830 Arixtra users. Check the latest studies of Arixtra.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,858 Dilantin users. Check the latest studies of Dilantin.

On Jul, 26, 2026

18 people who take Arixtra and Dilantin together, and have interactions are studied.

What are the common drug interactions of Arixtra and Dilantin, by gender? *:

female:

Oedema peripheral (superficial swelling)
Erythema (redness of the skin)
General physical health deterioration (weak health status)
Joint range of motion decreased (disease of joint movement)
Mobility decreased (ability to move is reduced)
Muscular weakness (muscle weakness)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Pruritus (severe itching of the skin)
Skin burning sensation

male:

Dehydration (dryness resulting from the removal of water)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Malaise (a feeling of general discomfort or uneasiness)
Neutropenia (an abnormally low number of neutrophils)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Peripheral swelling
Peripheral vascular disorder
Platelet count increased
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)

What are the common drug interactions of Arixtra and Dilantin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Asthenia (weakness)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Headache (pain in head)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Thrombocytopenia (decrease of platelets in blood)

30-39:

n/a

40-49:

Oedema peripheral (superficial swelling)
Erythema (redness of the skin)
General physical health deterioration (weak health status)
Joint range of motion decreased (disease of joint movement)
Mobility decreased (ability to move is reduced)
Muscular weakness (muscle weakness)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Pruritus (severe itching of the skin)
Skin burning sensation

50-59:

Erythema (redness of the skin)
General physical health deterioration (weak health status)
Joint range of motion decreased (disease of joint movement)
Mobility decreased (ability to move is reduced)
Muscular weakness (muscle weakness)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Pain
Pruritus (severe itching of the skin)
Skin burning sensation

60+:

Dehydration (dryness resulting from the removal of water)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Peripheral swelling
Peripheral vascular disorder
Platelet count increased
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary retention (the inability to completely or partially empty the bladder)
Urinary tract infection
White blood cell count increased
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))

What are the existing conditions these people have? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 7 people, 38.89%
Metastatic Carcinoma Of The Bladder (cancer types can spread to the bladder from other place): 6 people, 33.33%
Pulmonary Embolism (blockage of the main artery of the lung): 5 people, 27.78%
Nuclear Magnetic Resonance Imaging Brain: 3 people, 16.67%
Bladder Cancer: 2 people, 11.11%
Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 1 person, 5.56%
Primary Myelofibrosis (primary disorder of the bone marrow): 1 person, 5.56%
Polycystic Ovary Disease (cysts in the ovaries that occurs when the follicle stops developing): 1 person, 5.56%
Nuclear Magnetic Resonance Imaging Abdominal: 1 person, 5.56%
Multiple Myeloma (cancer of the plasma cells): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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