Arthrotec and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arthrotec (diclofenac sodium; misoprostol) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include blood thyroid stimulating hormone decreased among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Arthrotec and Hydroxyzine. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Arthrotec?

Arthrotec has active ingredients of diclofenac sodium; misoprostol. It is often used in arthritis. eHealthMe is studying from 11,986 Arthrotec users. Check the latest studies of Arthrotec.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,070 Hydroxyzine users. Check the latest studies of Hydroxyzine.

On Aug, 12, 2026

67 people who take Arthrotec and Hydroxyzine together, and have interactions are studied.

Arthrotec and Hydroxyzine drug interactions.

What are the common drug interactions of Arthrotec and Hydroxyzine, by gender? *:

female:

Blood thyroid stimulating hormone decreased
Capillary fragility (lack in resistance of capillary)
Dermal cyst
Osteoporosis (bones weak and more likely to break)
Hypertension (high blood pressure)
Back pain
Rehabilitation therapy
Vein disorder
Blood pressure fluctuation
Blood pressure increased

male:

Constipation
Diastolic dysfunction
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Arthralgia (joint pain)
Atrioventricular block first degree (heart block first degree)
Bone disorder
Bradycardia (abnormally slow heart action)
Cardiac murmur (an heart sound in valve abnormality)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Colon cancer

What are the common drug interactions of Arthrotec and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Arthralgia (joint pain)
Calcium deficiency (lack of calcium)
Contusion (a type of hematoma of tissue in which capillaries)
Depression
Fall
Haematemesis (vomiting of blood)
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc displacement
Intervertebral disc protrusion (spinal disc protrusion)
Lumbar radiculopathy (radicular pain in the low back and legs)

60+:

Glaucoma (increased fluid pressure in the eye with vision loss)
Erythema (redness of the skin)
Blood thyroid stimulating hormone decreased
Capillary fragility (lack in resistance of capillary)
Dermal cyst
Rehabilitation therapy
Vein disorder
Nausea (feeling of having an urge to vomit)
Cataract (clouding of the lens inside the eye)
Chronic kidney disease

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 22.39%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 13 people, 19.40%
Immunodeficiency: 11 people, 16.42%
Asthma: 11 people, 16.42%
Pain: 11 people, 16.42%
Depression: 10 people, 14.93%
Ankylosing Spondylitis (type of arthritis affecting the spine): 9 people, 13.43%
Primary Immunodeficiency Syndrome: 9 people, 13.43%
Diabetes: 9 people, 13.43%
Spondyloarthropathy (any joint disease of the vertebral column): 8 people, 11.94%

* Approximation only. Some reports may have incomplete information.

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