Asacol and Astelin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Asacol (mesalamine) and Astelin (azelastine hydrochloride). Common drug interactions include myocardial oedema among females and injection site pain among males.

The phase IV clinical study analyzes what interactions people have when they take Asacol and Astelin. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Asacol?

Asacol has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 20,618 Asacol users. Check the latest studies of Asacol.

What is Astelin?

Astelin has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 5,538 Astelin users. Check the latest studies of Astelin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

41 people who take Asacol and Astelin together, and have interactions are studied.

What are the common drug interactions of Asacol and Astelin, by gender? *:

female:

Myocardial oedema (heart muscle swelling)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Pain
Pneumonia
Pregnancy
Respiratory tract congestion (blockage on respiratory system)
Respiratory tract infection
Nausea (feeling of having an urge to vomit)
Headache (pain in head)
Weight increased

male:

Injection site pain
Asthenia (weakness)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Pain
Pyrexia (fever)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Vasoconstriction (constriction of blood vessels, which increases blood pressure)

What are the common drug interactions of Asacol and Astelin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abortion spontaneous (naturally occurring miscarriage)
Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)
Injection site pain
Pregnancy

40-49:

Acute respiratory failure
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Antinuclear antibody positive
Confusional state
Crying
Depression
Fatigue (feeling of tiredness)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Impaired driving ability
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)

50-59:

Chills (felling of cold)
Injection site rash
Nausea (feeling of having an urge to vomit)
Difficulty in walking
Dysarthria (speech disorder)
Dyspnoea (difficult or laboured respiration)
Dystonia (abnormal muscle tone)
Headache (pain in head)
Hot flush (sudden feelings of heat)
Injection site erythema (redness at injection site)

60+:

Weight increased
Nausea (feeling of having an urge to vomit)
Upper respiratory tract infection
Back injury
Bone disorder
Fall
Infusion related reaction
Malaise (a feeling of general discomfort or uneasiness)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Suicidal ideation

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 10 people, 24.39%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 21.95%
Apnea (temporary absence or cessation of breathing): 6 people, 14.63%
Sleep Apnea Syndrome: 4 people, 9.76%
Immunodeficiency Common Variable: 4 people, 9.76%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 9.76%
Drowsiness: 4 people, 9.76%
Menopausal Symptoms: 3 people, 7.32%
Hypersensitivity: 3 people, 7.32%
Depression: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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