Asacol and Zometa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Asacol (mesalamine) and Zometa (zoledronic acid). Common drug interactions include periodontitis among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Asacol and Zometa. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Asacol?

Asacol has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 20,618 Asacol users. Check the latest studies of Asacol.

What is Zometa?

Zometa has active ingredients of zoledronic acid. It is often used in multiple myeloma. eHealthMe is studying from 71,434 Zometa users. Check the latest studies of Zometa.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

96 people who take Asacol and Zometa together, and have interactions are studied.

What are the common drug interactions of Asacol and Zometa, by gender? *:

female:

Periodontitis (inflammation of the tissue around the teeth)
Pleural effusion (water on the lungs)
Anaemia (lack of blood)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Osteoporosis (bones weak and more likely to break)
Osteolysis (dissolution of bone)
Fatigue (feeling of tiredness)
Gingivitis (inflammation of gums)
Osteonecrosis of jaw (death of bone of jaw)
Swelling face

male:

Anxiety
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Arteriosclerosis (thickening and hardening of arteries)
Bone loss
Decreased interest
Exposed bone in jaw
Fear
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Osteoporosis (bones weak and more likely to break)
Patella fracture

What are the common drug interactions of Asacol and Zometa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cellulitis (infection under the skin)
Lung infection
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Stomatitis (inflammation of mucous membrane of mouth)

30-39:

n/a

40-49:

Diarrhoea
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Activities of daily living impaired
Adrenal disorder
Anxiety
Atelectasis (partial or complete collapse of the lung)
Bone loss
Cardiac failure congestive
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)

50-59:

Spinal osteoarthritis (joint cartilage loss in spine)
Swelling
Osteolysis (dissolution of bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Diarrhoea
Aptyalism (deficiency or absence of saliva)
Bone disorder
Bone erosion
Exostosis (formation of new bone on the surface of a bone)
Generalised oedema (swelling all over the body)

60+:

Osteomyelitis (infection of bone)
Arteriosclerosis (thickening and hardening of arteries)
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Hypotension (abnormally low blood pressure)
Intervertebral disc degeneration (spinal disc degeneration)
Joint effusion (presence of extra fluid in joint covering)
Osteitis (a general term for inflammation of bone)
Osteonecrosis of jaw (death of bone of jaw)
Osteoporosis (bones weak and more likely to break)

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 34 people, 35.42%
Osteoporosis (bones weak and more likely to break): 34 people, 35.42%
Osteopenia (a condition where bone mineral density is lower than normal): 18 people, 18.75%
Thrombocytopenia (decrease of platelets in blood): 11 people, 11.46%
Metastases To Bone (cancer spreads to bone): 11 people, 11.46%
Pain: 10 people, 10.42%
Colitis (inflammation of colon): 8 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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