Astelin and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Astelin (azelastine hydrochloride) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include cough among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Astelin and Excedrin. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Astelin?

Astelin has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 5,538 Astelin users. Check the latest studies of Astelin.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

On Jul, 12, 2026

26 people who take Astelin and Excedrin together, and have interactions are studied.

What are the common drug interactions of Astelin and Excedrin, by gender? *:

female:

Cough
Dizziness
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Sinusitis (inflammation of sinus)
Anxiety
Cellulitis (infection under the skin)
Chills (felling of cold)
Diarrhoea

male:

Back pain
Fatigue (feeling of tiredness)
Acanthosis (thickening of the skin)
Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Acute sinusitis
Anxiety
Asthenia (weakness)
Asthma
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the common drug interactions of Astelin and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Fatigue (feeling of tiredness)
Pain in extremity
Arthralgia (joint pain)
Back pain
Cellulitis (infection under the skin)
Concussion (short loss of normal brain function in response to a head injury)
Fasciitis (infection of muscle surrounding tissue)
Head injury
Impaired healing
Injection site erythema (redness at injection site)

40-49:

Nausea (feeling of having an urge to vomit)
Chills (felling of cold)
Sinusitis (inflammation of sinus)
Abdominal distension
Defaecation urgency (a sudden compelling urge to defecate)
Diarrhoea
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Laryngitis (inflammation of the larynx)
Malaise (a feeling of general discomfort or uneasiness)
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Contusion (a type of hematoma of tissue in which capillaries)
Dizziness
Dysgeusia (disorder of the sense of taste)
Exercise tolerance decreased
Face oedema (swelling of face)
Fatigue (feeling of tiredness)
Joint swelling
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)
Abdominal distension

60+:

Dizziness
Dyspnoea (difficult or laboured respiration)
Adrenal mass
Anastomotic stenosis
Anastomotic ulcer
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Appendicitis (inflammation of the appendix)
Areflexia (absence of a reflex)
Arterial disorder

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 5 people, 19.23%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 11.54%
High Blood Cholesterol: 3 people, 11.54%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 7.69%
Neoplasm Malignant (cancer tumour): 2 people, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.69%
Bone Loss: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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