Astelin and Fioricet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Astelin (azelastine hydrochloride) and Fioricet (acetaminophen; butalbital; caffeine). Common drug interactions include agitation among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Astelin and Fioricet. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Astelin?

Astelin has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 5,538 Astelin users. Check the latest studies of Astelin.

What is Fioricet?

Fioricet has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 12,423 Fioricet users. Check the latest studies of Fioricet.

On Jul, 09, 2026

60 people who take Astelin and Fioricet together, and have interactions are studied.

What are the common drug interactions of Astelin and Fioricet, by gender? *:

female:

Agitation (state of anxiety or nervous excitement)
Ankle fracture
Anxiety
Arrhythmia (irregular heartbeat)
Biliary dilatation
Chills (felling of cold)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Contusion (a type of hematoma of tissue in which capillaries)
Deafness
Depression

male:

Back pain
Blood pressure increased
Cough
Anaphylactic reaction (serious allergic reaction)
Arteriovenous malformation
Cardiomegaly (increased size of heart than normal)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Dental caries
Drug hypersensitivity
Dysphagia (a condition in which swallowing is difficult or painful)

What are the common drug interactions of Astelin and Fioricet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Acne cystic (skin problems that cause pimples)
Anaemia (lack of blood)
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Back pain
Blood cholesterol increased
Blood pressure increased
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cholangitis (infection of the bile duct)

40-49:

Arteriovenous malformation
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Dental caries
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Intervertebral disc protrusion (spinal disc protrusion)
Microcytic anaemia (a generic term for any type of anaemia characterized by small red blood cells)
Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Pain

50-59:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dizziness
Dry eye (lack of adequate tears)
Dyskinesia (abnormality or impairment of voluntary movement)
Dysplasia (enlargement of an organ or tissue)
Dystonia (abnormal muscle tone)
Emotional disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Facial pain
Faeces discoloured

60+:

Fatigue (feeling of tiredness)
Arrhythmia (irregular heartbeat)
Osteoporosis (bones weak and more likely to break)
Pain
Spinal cord disorder (disease of spinal cord)
Thyroid disorder (thyroid diseases)
Agitation (state of anxiety or nervous excitement)
Anxiety
Bone marrow failure
Brain injury

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 30 people, 50.00%
Asthma: 6 people, 10.00%
Pain: 5 people, 8.33%
Immunodeficiency Common Variable: 4 people, 6.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 6.67%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 5.00%
Nausea (feeling of having an urge to vomit): 3 people, 5.00%
High Blood Pressure: 3 people, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Astelin and Fioricet?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously