Astepro and Aldactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Astepro (azelastine hydrochloride) and Aldactone (spironolactone). Common drug interactions include chronic kidney disease among females and osteoarthritis among males.

The phase IV clinical study analyzes what interactions people have when they take Astepro and Aldactone. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Astepro?

Astepro has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 3,336 Astepro users. Check the latest studies of Astepro.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

On Jul, 06, 2026

20 people who take Astepro and Aldactone together, and have interactions are studied.

Astepro and Aldactone drug interactions.

What are the common drug interactions of Astepro and Aldactone, by gender? *:

female:

Chronic kidney disease
Dehydration (dryness resulting from the removal of water)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Dizziness
Dry mouth
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Nasal discomfort
Nasal dryness (dry nose)

male:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cough
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Disease progression
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)

What are the common drug interactions of Astepro and Aldactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dehydration (dryness resulting from the removal of water)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)

30-39:

n/a

40-49:

Back pain
Cardiac failure
Dyspnoea (difficult or laboured respiration)
Infusion site erythema (reddening of the skin at infusion site)
Oedema peripheral (superficial swelling)
Pyrexia (fever)
Weight increased

50-59:

Chronic kidney disease
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Urinary tract infection

60+:

Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Nasal dryness (dry nose)
Thirst
Arthralgia (joint pain)
Back pain
Bradycardia (abnormally slow heart action)
Cardiac failure congestive
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 30.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 15.00%
Nausea (feeling of having an urge to vomit): 2 people, 10.00%
Immunodeficiency Common Variable: 2 people, 10.00%
Stress And Anxiety: 1 person, 5.00%
Humoral Immune Defect (impairment of humoral immunity): 1 person, 5.00%
Back Pain: 1 person, 5.00%
Cerebrovascular Disorder (disease of brain): 1 person, 5.00%
Constipation: 1 person, 5.00%
Drowsiness: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Astepro and Aldactone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously