Astepro and Promethazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Astepro (azelastine hydrochloride) and Promethazine (promethazine hydrochloride). Common drug interactions include alopecia among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Astepro and Promethazine. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Astepro?

Astepro has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 3,336 Astepro users. Check the latest studies of Astepro.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

On Jul, 10, 2026

64 people who take Astepro and Promethazine together, and have interactions are studied.

Astepro and Promethazine drug interactions.

What are the common drug interactions of Astepro and Promethazine, by gender? *:

female:

Alopecia (absence of hair from areas of the body)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Arthralgia (joint pain)
Arthroscopic surgery
Cellulitis (infection under the skin)
Chest discomfort
Corneal disorder
Dehydration (dryness resulting from the removal of water)
Dry skin
Dysphonia (speech disorder attributable to a disorder of phonation)

male:

Renal failure (kidney dysfunction)
Asthenia (weakness)
Obstruction
Weight decreased
Blood pressure fluctuation
Lip infection (infection of lip)
Respiratory tract congestion (blockage on respiratory system)
Skin infection
Arthralgia (joint pain)
Dizziness

What are the common drug interactions of Astepro and Promethazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Asthenia (weakness)
Dysgeusia (disorder of the sense of taste)
Headache (pain in head)
Parosmia (distortion of the sense of smell, as in smelling odours that are not present)
Rhinorrhoea (watery mucus discharge from the nose)
Sneezing

30-39:

n/a

40-49:

Chest discomfort
Loss of consciousness
Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)
Abdominal pain
Alopecia (absence of hair from areas of the body)
Anxiety
Bladder disorder
Cholecystitis chronic (long lasting infection of gallbladder)
Cystitis escherichia (inflammation of the wall of the bladder by bacteria escherichia coli)
Dry eye (lack of adequate tears)

50-59:

Urticaria (rash of round, red welts on the skin that itch intensely)
Vision blurred
Abdominal pain upper
Alopecia (absence of hair from areas of the body)
Anxiety
Back pain
Blood creatine phosphokinase increased
Chest pain
Constipation
Depression

60+:

Renal failure (kidney dysfunction)
Asthenia (weakness)
Obstruction
Weight decreased
Blood pressure fluctuation
Lip infection (infection of lip)
Respiratory tract congestion (blockage on respiratory system)
Skin infection
Arthralgia (joint pain)
Dizziness

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 24 people, 37.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 20.31%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 15.62%
High Blood Pressure: 9 people, 14.06%
Hypersensitivity: 8 people, 12.50%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 12.50%
Asthma: 8 people, 12.50%
Pain: 5 people, 7.81%
High Blood Cholesterol: 5 people, 7.81%
Drowsiness: 5 people, 7.81%

* Approximation only. Some reports may have incomplete information.

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