Ativan and Fetzima drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ativan (lorazepam) and Fetzima (levomilnacipran hydrochloride). Common drug interactions include heart rate increased among females and pericarditis among males.

The phase IV clinical study analyzes what interactions people have when they take Ativan and Fetzima. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Ativan?

Ativan has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 78,506 Ativan users. Check the latest studies of Ativan.

What is Fetzima?

Fetzima has active ingredients of levomilnacipran hydrochloride. It is often used in depression. eHealthMe is studying from 2,077 Fetzima users. Check the latest studies of Fetzima.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

34 people who take Ativan and Fetzima together, and have interactions are studied.

What are the common drug interactions of Ativan and Fetzima, by gender? *:

female:

Heart rate increased
Injection site swelling
Pain
Decreased appetite
Bipolar disorder (mood disorder)
Blindness
Cardiac flutter (abnormal heart rhythm)
Chest discomfort
Depressed mood
Euphoric mood (excessively happy but may become angry or irritable)

male:

Pericarditis (inflammation of the pericardium)
Nipple pain
Nipple swelling
Chest pain
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

What are the common drug interactions of Ativan and Fetzima, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pericarditis (inflammation of the pericardium)
Blood pressure increased
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Back pain
Cardiac flutter (abnormal heart rhythm)
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Euphoric mood (excessively happy but may become angry or irritable)
Fatigue (feeling of tiredness)
Oedema peripheral (superficial swelling)

40-49:

Blindness
Joint swelling
Death
Heart rate increased
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Injection site erythema (redness at injection site)
Injection site swelling

50-59:

Vision blurred
Visual impairment
Agitation (state of anxiety or nervous excitement)
Dry mouth
Heart rate increased
Asthenia (weakness)
Bipolar disorder (mood disorder)
Blood cholesterol increased
Blood pressure fluctuation
Body temperature fluctuation

60+:

Depressed mood
Palpitations (feelings or sensations that your heart is pounding or racing)
Fat tissue increased
Hyperglycaemia (high blood sugar)
Hyperlipidaemia (presence of excess lipids in the blood)
Lymphadenopathy (disease or enlargement of lymph nodes)
Mobility decreased (ability to move is reduced)
Nausea (feeling of having an urge to vomit)
Pain
Periodic limb movement disorder

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 23.53%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 14.71%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 11.76%
Pain: 4 people, 11.76%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 3 people, 8.82%
Thyroid Cancer: 2 people, 5.88%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 5.88%
Migraine (headache): 2 people, 5.88%
High Blood Pressure: 2 people, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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