Atripla and Marijuana drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Atripla (efavirenz; emtricitabine; tenofovir disoproxil fumarate) and Marijuana (marijuana). Common drug interactions include anhedonia among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Atripla and Marijuana. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Atripla?

Atripla has active ingredients of efavirenz; emtricitabine; tenofovir disoproxil fumarate. It is often used in hiv infection. eHealthMe is studying from 36,036 Atripla users. Check the latest studies of Atripla.

What is Marijuana?

Marijuana has active ingredients of marijuana. It is often used in stress and anxiety. eHealthMe is studying from 7,397 Marijuana users. Check the latest studies of Marijuana.



On Jul, 04, 2026

18 people who take Atripla and Marijuana together, and have interactions are studied.

Atripla and Marijuana drug interactions.

What are the common drug interactions of Atripla and Marijuana, by gender? *:

female:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Emotional distress
  3. Chronic kidney disease
  4. Decreased activity
  5. Foot fracture
  6. Multiple fractures
  7. Osteoporosis (bones weak and more likely to break)
  8. Renal failure (kidney dysfunction)
  9. Blood creatinine increased
  10. Bone density decreased

male:

  1. Emotional distress
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Proteinuria (presence of protein in the urine)
  4. Chronic kidney disease
  5. Multiple injuries
  6. Headache (pain in head)
  7. Nausea (feeling of having an urge to vomit)
  8. Conjunctival haemorrhage (bleeding underneath the conjunctiva)
  9. Cryptorchism
  10. Dry mouth

What are the common drug interactions of Atripla and Marijuana, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Abdominal pain
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Arthralgia (joint pain)
  4. Back pain
  5. Bipolar disorder (mood disorder)
  6. Bone density decreased
  7. Emotional distress
  8. Kidney infection
  9. Testicular disorder (disease of testes)
  10. Tooth loss

40-49:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Emotional distress
  3. Chronic kidney disease
  4. Renal failure (kidney dysfunction)
  5. Multiple injuries
  6. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  7. Osteoporosis (bones weak and more likely to break)

50-59:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Emotional distress
  3. Bone density decreased
  4. Fatigue (feeling of tiredness)
  5. Gait disturbance
  6. Renal impairment (severely reduced kidney function)
  7. Chronic kidney disease
  8. Multiple injuries
  9. Decreased activity
  10. Foot fracture

60+:

n/a

What are the existing conditions these people have? *

  1. Depression: 5 people, 27.78%
  2. Pain: 3 people, 16.67%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 16.67%
  4. Bipolar Disorder (mood disorder): 3 people, 16.67%
  5. High Blood Cholesterol: 2 people, 11.11%
  6. Schizoaffective Disorder (a mental disorder characterized by disordered thought): 1 person, 5.56%
  7. Renal Disorder (kidney disease): 1 person, 5.56%
  8. Nausea (feeling of having an urge to vomit): 1 person, 5.56%
  9. Migraine (headache): 1 person, 5.56%
  10. Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Atripla and Marijuana:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Atripla:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Marijuana:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Atripla and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Marijuana and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on efavirenz; emtricitabine; tenofovir disoproxil fumarate and marijuana (the active ingredients of Atripla and Marijuana, respectively), and Atripla and Marijuana (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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