Atripla and Zosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Atripla (efavirenz; emtricitabine; tenofovir disoproxil fumarate) and Zosyn (piperacillin sodium; tazobactam sodium). Common drug interactions include anhedonia among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Atripla and Zosyn. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Atripla?

Atripla has active ingredients of efavirenz; emtricitabine; tenofovir disoproxil fumarate. It is often used in hiv infection. eHealthMe is studying from 36,036 Atripla users. Check the latest studies of Atripla.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

On Dec, 22, 2025

17 people who take Atripla and Zosyn together, and have interactions are studied.

What are the common drug interactions of Atripla and Zosyn, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Decreased activity
Fatigue (feeling of tiredness)
Mobility decreased (ability to move is reduced)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Quality of life decreased

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
General physical health deterioration (weak health status)
Mobility decreased (ability to move is reduced)
Renal tubular necrosis (death of kidney tubules)
Tooth loss
Decreased activity
Fatigue (feeling of tiredness)
Injury
Osteonecrosis (death of bone)

What are the common drug interactions of Atripla and Zosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Death
Emotional distress
Pain
Renal failure (kidney dysfunction)
Tooth loss

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Emotional distress
Multiple fractures
Pain
Tooth loss

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Renal tubular necrosis (death of kidney tubules)
Chronic kidney disease
Decreased activity
Fatigue (feeling of tiredness)
Injury
Osteonecrosis (death of bone)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Pain
Haematuria (presence of blood in urine)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Anaemia of chronic disease
Bone density decreased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chronic kidney disease
Fistula (an abnormal connection or passageway between two)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Tooth loss

What are the existing conditions these people have? *

Paronychia (infection in the tissues adjacent to a nail on a finger or toe): 2 people, 11.76%
Itching: 2 people, 11.76%
Headache (pain in head): 2 people, 11.76%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 2 people, 11.76%
Diarrhea: 2 people, 11.76%
Cellulitis (infection under the skin): 2 people, 11.76%
Anaemia Of Chronic Disease: 2 people, 11.76%
Pilonidal Cyst: 1 person, 5.88%
Abscess Jaw (tooth abscess or root abscess): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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