Augmentin and Avandamet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Augmentin (amoxicillin; clavulanate potassium) and Avandamet (metformin hydrochloride; rosiglitazone maleate). Common drug interactions include actinomycosis among females and diabetic neuropathy among males.

The phase IV clinical study analyzes what interactions people have when they take Augmentin and Avandamet. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

What is Avandamet?

Avandamet has active ingredients of metformin hydrochloride; rosiglitazone maleate. It is often used in diabetes. eHealthMe is studying from 16,084 Avandamet users. Check the latest studies of Avandamet.

On Jul, 13, 2026

22 people who take Augmentin and Avandamet together, and have interactions are studied.

Augmentin and Avandamet drug interactions.

What are the common drug interactions of Augmentin and Avandamet, by gender? *:

female:

Actinomycosis (infection that causes sores, or abscesses)
Acute monocytic leukaemia (a type of blood cancer)
Adverse event
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Angioedema (rapid swelling of the dermis)
Anxiety
Arrhythmia (irregular heartbeat)

male:

Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Fatigue (feeling of tiredness)
Obesity (having too much body fat)
Oedema peripheral (superficial swelling)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Weight increased
Abdominal pain upper
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthenia (weakness)
Congestive cardiomyopathy (weakening of heart muscle)

What are the common drug interactions of Augmentin and Avandamet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Obesity (having too much body fat)
Overdose
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Scrotal pain
Scrotal swelling
Suicidal ideation
Suicide attempt

30-39:

n/a

40-49:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Arteriosclerosis (thickening and hardening of arteries)
Asthenia (weakness)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

50-59:

Essential hypertension (primary hypertension)
Face oedema (swelling of face)
Facial pain
Gastroenteritis (inflammation of stomach and intestine)
Gastrointestinal motility disorder (abnormal intestinal contractions)
Hallucination (an experience involving the perception of something not present)
Hypertrophy (increase in the volume of an organ or tissue due to the enlargement of its component cells)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)

60+:

Abdominal pain
Abdominal pain upper
Hepatic steatosis (fatty liver disease)
Hypovolaemic shock (shock caused by severe blood or fluid loss)
Nausea (feeling of having an urge to vomit)
Vomiting
Nephritis interstitial (a kidney condition characterized by swelling in between the kidney tubules)
Renal failure acute (rapid kidney dysfunction)
Acute monocytic leukaemia (a type of blood cancer)
Arterial thrombosis (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system)

What are the existing conditions these people have? *

Urinary Tract Infection: 2 people, 9.09%
Thrombosis (formation of a blood clot inside a blood vessel): 2 people, 9.09%
Sleep Disorder: 2 people, 9.09%
Depression: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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