Augmentin and Clindamycin hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Augmentin (amoxicillin; clavulanate potassium) and Clindamycin hydrochloride (clindamycin hydrochloride). Common drug interactions include malaise among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Augmentin and Clindamycin hydrochloride. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

What is Clindamycin hydrochloride?

Clindamycin hydrochloride has active ingredients of clindamycin hydrochloride. It is often used in tooth abscess. eHealthMe is studying from 4,257 Clindamycin hydrochloride users. Check the latest studies of Clindamycin hydrochloride.

On Jul, 10, 2026

73 people who take Augmentin and Clindamycin hydrochloride together, and have interactions are studied.

Augmentin and Clindamycin hydrochloride drug interactions.

What are the common drug interactions of Augmentin and Clindamycin Hydrochloride, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Pneumonia mycoplasmal (mycoplasma pneumonia (mp) is a contagious respiratory infection)
Seasonal allergy (allergic condition due to certain season)
Abdominal discomfort
Allergic sinusitis
Anxiety
Blood sodium increased
Diarrhoea
Diplopia (double vision)
Dyspnoea (difficult or laboured respiration)

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Dental fistula
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Emotional distress
Lacrimation increased
Laryngeal discomfort

What are the common drug interactions of Augmentin and Clindamycin Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Electrocardiogram qt prolonged

10-19:

n/a

20-29:

Blood fibrinogen increased
C-reactive protein increased
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
Erythema (redness of the skin)
Erythema multiforme (a type of hypersensitivity reaction)
Face oedema (swelling of face)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypoproteinaemia (too little prolactin circulating in the blood)
Lymphocytosis (an increase in the number or proportion of lymphocytes in the blood)

30-39:

Drug ineffective
Conjunctivitis (pink eye)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Lacrimation increased
Ocular hyperaemia (an abnormally large amount of blood in eye)
Chronic kidney disease
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Injection site swelling
Nephrogenic anaemia (anaemia due to kidney disease)

40-49:

Dyspnoea (difficult or laboured respiration)
Blood potassium decreased
Blood pressure increased
Breast enlargement
Chest pain
Clamminess (moist, sticky, and cold to the touch)
Confusion
Coordination abnormal (abnormal movement)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Difficulty in micturition (difficulty to urinate)

50-59:

Eye irritation
Haematuria (presence of blood in urine)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatorenal syndrome (renal failure in patients with advanced chronic liver disease)
Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
Lacrimation increased
Leukocyturia (presence of white blood cells in urine)
Liver disorder (liver diseases)
Loss of consciousness
Lung disorder (lung disease)

60+:

Cough
Pain
Oral infection
Gastrointestinal inflammation (inflammation of stomach and intestine)
Pneumonia mycoplasmal (mycoplasma pneumonia (mp) is a contagious respiratory infection)
Seasonal allergy (allergic condition due to certain season)
Allergic sinusitis
Injection site erythema (redness at injection site)
Injection site pain
Back pain

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 14 people, 19.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 12.33%
Pain: 8 people, 10.96%
High Blood Pressure: 8 people, 10.96%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 9.59%
Impaired Healing: 7 people, 9.59%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 9.59%
Adverse Event: 7 people, 9.59%
Infection: 5 people, 6.85%
High Blood Cholesterol: 4 people, 5.48%

* Approximation only. Some reports may have incomplete information.

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