Augmentin and Ibrutinib drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Augmentin (amoxicillin; clavulanate potassium) and Ibrutinib (ibrutinib). Common drug interactions include stomatitis among females and subdural haematoma among males.

The phase IV clinical study analyzes what interactions people have when they take Augmentin and Ibrutinib. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

What is Ibrutinib?

Ibrutinib has active ingredients of ibrutinib. eHealthMe is studying from 13,529 Ibrutinib users. Check the latest studies of Ibrutinib.

On Jul, 12, 2026

80 people who take Augmentin and Ibrutinib together, and have interactions are studied.

Augmentin and Ibrutinib drug interactions.

What are the common drug interactions of Augmentin and Ibrutinib, by gender? *:

female:

Stomatitis (inflammation of mucous membrane of mouth)
Vertigo
Cardiac failure
Weight decreased
Anaemia (lack of blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cerebellar ischaemia (lack of blood supply to cerebeller)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Haematotoxicity (toxins that destroy red blood cells)
Hyperkalaemia (damage to or disease of the kidney)

male:

Subdural haematoma (blood collects between the skull and the surface of the brain)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Pyrexia (fever)
Haematoma (collection of blood outside the blood vessels)
Pleuritic pain
Vomiting
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Coagulopathy (blood's ability to clot is impaired)
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Gastroenteritis clostridial (inflammation of stomach and intestine clostridial)

What are the common drug interactions of Augmentin and Ibrutinib, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hyperkalaemia (damage to or disease of the kidney)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Abdominal pain
Diarrhoea
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Epistaxis (bleed from the nose)
Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
General physical health deterioration (weak health status)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)

40-49:

Skin ulcer
Haematoma infection (infection with collection of blood outside the blood vessels)
Haematuria (presence of blood in urine)
Hyperthermia (body temperature greatly above normal)
Penile oedema (penis swelling)

50-59:

Sinusitis fungal (fungal infection of sinus)
Stomatitis (inflammation of mucous membrane of mouth)
Vertigo
Infectious pleural effusion (infectious fluid in the lung)
Haematoma (collection of blood outside the blood vessels)
Lung infection
Pleuritic pain
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Cystitis noninfective (non-infectious inflammation of the wall of the bladder)
Orchitis (inflammation of the testes)

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Pyrexia (fever)
Anaemia (lack of blood)
Cardiac failure
Fatigue (feeling of tiredness)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Coagulopathy (blood's ability to clot is impaired)
Gastroenteritis clostridial (inflammation of stomach and intestine clostridial)
Hyperkalaemia (damage to or disease of the kidney)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)

What are the existing conditions these people have? *

Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 38 people, 47.50%
Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 21 people, 26.25%
Pain: 17 people, 21.25%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 11 people, 13.75%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 10 people, 12.50%
Fever: 10 people, 12.50%
Constipation: 8 people, 10.00%
Mucosal Inflammation (infection of mucous membrane): 8 people, 10.00%
High Blood Pressure: 8 people, 10.00%
Hypokalemia (low potassium): 7 people, 8.75%

* Approximation only. Some reports may have incomplete information.

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