Augmentin and Kadian drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Augmentin (amoxicillin; clavulanate potassium) and Kadian (morphine sulfate). Common drug interactions include injection site urticaria among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Augmentin and Kadian. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

What is Kadian?

Kadian has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 23,045 Kadian users. Check the latest studies of Kadian.

On Jul, 26, 2026

20 people who take Augmentin and Kadian together, and have interactions are studied.

What are the common drug interactions of Augmentin and Kadian, by gender? *:

female:

Injection site urticaria (rash of round, red welts on the skin at injection site)
Jaw fracture
Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back))
Loose tooth
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Mastication disorder (disease of chewing food)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Mucosal inflammation (infection of mucous membrane)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Discomfort
Dyspnoea (difficult or laboured respiration)
Emotional distress
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypophagia (reduced food intake)
Hypotension (abnormally low blood pressure)
Jaw fracture
Loose tooth

What are the common drug interactions of Augmentin and Kadian, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Acute myocardial infarction (acute heart attack)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Atelectasis (partial or complete collapse of the lung)
Bone disorder
Coagulopathy (blood's ability to clot is impaired)
Deformity (disfigurement)
Discomfort
Dyspnoea (difficult or laboured respiration)
Emotional distress

50-59:

Cellulitis (infection under the skin)
Constipation
Fatigue (feeling of tiredness)
Haematocrit decreased
Haemoglobin decreased
Influenza
International normalised ratio increased
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Oxygen consumption increased

60+:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 8 people, 40.00%
High Blood Pressure: 5 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 25.00%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 15.00%
Stress And Anxiety: 1 person, 5.00%
Osteoporosis (bones weak and more likely to break): 1 person, 5.00%
Migraine (headache): 1 person, 5.00%
Immunodeficiency Common Variable: 1 person, 5.00%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 1 person, 5.00%
Hypersensitivity: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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