Augmentin and Methylcobalamin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Augmentin (amoxicillin; clavulanate potassium) and Methylcobalamin (vitamin b12). Common drug interactions include pyrexia among females and diverticulitis among males.

The phase IV clinical study analyzes what interactions people have when they take Augmentin and Methylcobalamin. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

What is Methylcobalamin?

Methylcobalamin has active ingredients of vitamin b12. It is often used in vitamin b12 deficiency. eHealthMe is studying from 3,184 Methylcobalamin users. Check the latest studies of Methylcobalamin.

On Jul, 13, 2026

17 people who take Augmentin and Methylcobalamin together, and have interactions are studied.

Augmentin and Methylcobalamin drug interactions.

What are the common drug interactions of Augmentin and Methylcobalamin, by gender? *:

female:

Pyrexia (fever)
Abortion spontaneous (naturally occurring miscarriage)
Asthma
Cough
Glycosylated haemoglobin decreased
Maternal exposure during pregnancy (use of substance during pregnancy)
Muscular weakness (muscle weakness)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Oropharyngeal pain
Pain in extremity

male:

Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Oedema peripheral (superficial swelling)
Colonic fistula (abnormal passage to other organ from colon)
Decreased appetite
Dermatitis exfoliative generalised (inflammatory skin disease with erythema and scaling that affects nearly the entire cutaneous surface)
Dysphonia (speech disorder attributable to a disorder of phonation)
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Foot fracture
Fracture
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)

What are the common drug interactions of Augmentin and Methylcobalamin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abortion spontaneous (naturally occurring miscarriage)
Cough
Glycosylated haemoglobin decreased
Maternal exposure during pregnancy (use of substance during pregnancy)
Muscular weakness (muscle weakness)
Oropharyngeal pain
Pain in extremity
Pyrexia (fever)

30-39:

Shunt occlusion (blockage of shunt)
Asthma
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Sinus disorder (disease of sinus)
Colonic fistula (abnormal passage to other organ from colon)
Decreased appetite
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Fall
Fracture
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)

40-49:

Abdominal discomfort
Aptyalism (deficiency or absence of saliva)
Fatigue (feeling of tiredness)
Glucose urine present
Hyperhidrosis (abnormally increased sweating)
Hypothalamo-pituitary disorder (loss of function in an endocrine gland due to failure of the pituitary gland to secrete hormones which stimulate that gland's function)
Pyrexia (fever)
Surgery
Tooth extraction

50-59:

Abdominal pain upper
Thrombosis (formation of a blood clot inside a blood vessel)

60+:

Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Oedema peripheral (superficial swelling)
Foot fracture
Nausea (feeling of having an urge to vomit)
Peripheral motor neuropathy (muscles in the body become progressively weaker over months to years)
Peripheral sensory neuropathy (damage to one or more of your peripheral nerves)
Pruritus (severe itching of the skin)
Pyrexia (fever)
Rash
Renal impairment (severely reduced kidney function)

What are the existing conditions these people have? *

Diabetes: 5 people, 29.41%
Type 2 Diabetes: 2 people, 11.76%
Constipation: 2 people, 11.76%
Multiple Myeloma (cancer of the plasma cells): 2 people, 11.76%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 2 people, 11.76%
Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 2 people, 11.76%
Allergic Rhinitis: 2 people, 11.76%
Folate Deficiency (lack of folic acid): 2 people, 11.76%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1 person, 5.88%
Cardiac Failure Congestive: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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