Augmentin and Naproxen sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Augmentin (amoxicillin; clavulanate potassium) and Naproxen sodium (naproxen sodium). Common drug interactions include pain in jaw among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Augmentin and Naproxen sodium. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

What is Naproxen sodium?

Naproxen sodium has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 11,252 Naproxen sodium users. Check the latest studies of Naproxen sodium.

On Jul, 20, 2026

59 people who take Augmentin and Naproxen sodium together, and have interactions are studied.

Augmentin and Naproxen sodium drug interactions.

What are the common drug interactions of Augmentin and Naproxen Sodium, by gender? *:

female:

Pain in jaw
Upper respiratory tract infection
Anaemia (lack of blood)
Arthralgia (joint pain)
Cancer pain
Chest discomfort
Chronic kidney disease
Compression fracture (fracture due to pressure caused by injury)
Erythema (redness of the skin)
Influenza

male:

Asthenia (weakness)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Faecal incontinence (a lack of control over passing stool)
Fall
Gait disturbance
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hallucination (an experience involving the perception of something not present)
Headache (pain in head)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oedema peripheral (superficial swelling)

What are the common drug interactions of Augmentin and Naproxen Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hallucination (an experience involving the perception of something not present)
Henoch-schonlein purpura (inflammation of the blood vessels in the skin and other body organs)
Joint swelling
Oedema peripheral (superficial swelling)
Persecutory delusion
Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)
Rash
Suicide attempt
Vasculitis (inflammation of a blood vessel or blood vessels)

20-29:

Acne (skin problems that cause pimples)
Cholecystitis chronic (long lasting infection of gallbladder)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Erythema nodosum (skin inflammation that results in reddish, painful, tender lumps most commonly located in the front of the legs below)
Gallbladder injury
Hallucination, auditory (perceiving sounds without auditory stimulus)
Injury
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Pancreatitis acute (sudden inflammation of pancreas)
Skin lesion

30-39:

Blood triglycerides increased
Cellulitis (infection under the skin)
Diabetes mellitus non-insulin-dependent
Erectile dysfunction
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oedema peripheral (superficial swelling)
Sinus disorder (disease of sinus)
Weight increased

40-49:

Cancer pain
Drug hypersensitivity
Metastases to liver (cancer spreads to liver)
Metastases to lymph nodes (cancer spreads to lymph node)
Metastases to peritoneum (cancer spreads to peritoneum)
Chronic kidney disease
Decreased appetite
Febrile neutropenia (fever with reduced white blood cells)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Metastases to bone (cancer spreads to bone)

50-59:

Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Abscess (pus)
Abscess limb (limb infection)
Anal abscess
Cellulitis (infection under the skin)
Chronic kidney disease
Colitis (inflammation of colon)
Constipation
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Drug hypersensitivity

60+:

Exposed bone in jaw
Gingival infection (gum infection)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dysarthria (speech disorder)
Faecal incontinence (a lack of control over passing stool)
Fall
Gait disturbance
Hallucination (an experience involving the perception of something not present)
Arthralgia (joint pain)
Compression fracture (fracture due to pressure caused by injury)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 11 people, 18.64%
Insomnia (sleeplessness): 8 people, 13.56%
Diabetes: 6 people, 10.17%
Asthma: 5 people, 8.47%
Stress And Anxiety: 4 people, 6.78%
Nausea (feeling of having an urge to vomit): 4 people, 6.78%
Migraine (headache): 4 people, 6.78%
Seasonal Allergy (allergic condition due to certain season): 3 people, 5.08%
Osteomyelitis (infection of bone): 3 people, 5.08%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 5.08%

* Approximation only. Some reports may have incomplete information.

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