Augmentin and Palladone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Augmentin (amoxicillin; clavulanate potassium) and Palladone (hydromorphone hydrochloride). Common drug interactions include febrile neutropenia among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Augmentin and Palladone. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

What is Palladone?

Palladone has active ingredients of hydromorphone hydrochloride. eHealthMe is studying from 2,546 Palladone users. Check the latest studies of Palladone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

12 people who take Augmentin and Palladone together, and have interactions are studied.

Augmentin and Palladone drug interactions.

What are the common drug interactions of Augmentin and Palladone, by gender? *:

female:

Febrile neutropenia (fever with reduced white blood cells)
Appetite disorder (abnormal eating habits)
Asthma
Cough
Drug ineffective
General physical health deterioration (weak health status)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Overdose
Relapsing fever (bacterial infection characterized by recurring episodes of fever, headache, muscle and joint aches, and nausea)
Skin discolouration (change of skin colour)

male:

Dehydration (dryness resulting from the removal of water)
Blood creatinine increased
Arterial insufficiency (lack of enough blood flow through the arteries)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Ascites (accumulation of fluid in the abdominal cavity)
Asterixis (flapping tremor, or liver flap)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Balance disorder

What are the common drug interactions of Augmentin and Palladone, by age (0-1 to 60+)? *:

0-1:

Acidosis (build-up of carbon dioxide in the blood)
Respiratory depression (respiration has a rate below 12 breaths)

2-9:

Appetite disorder (abnormal eating habits)
Asthma
Cough
Drug ineffective
Febrile neutropenia (fever with reduced white blood cells)
General physical health deterioration (weak health status)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Overdose
Relapsing fever (bacterial infection characterized by recurring episodes of fever, headache, muscle and joint aches, and nausea)
Skin discolouration (change of skin colour)

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Febrile neutropenia (fever with reduced white blood cells)
Cardiac failure
Alcoholic liver disease
Anaemia (lack of blood)
Anxiety
Aortic valve calcification
Arterial insufficiency (lack of enough blood flow through the arteries)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Ascites (accumulation of fluid in the abdominal cavity)

What are the existing conditions these people have? *

Infection: 7 people, 58.33%
Osteoporosis (bones weak and more likely to break): 7 people, 58.33%
Glaucoma (increased fluid pressure in the eye with vision loss): 7 people, 58.33%
High Blood Pressure: 7 people, 58.33%
Myeloma Recurrence (recurrence of cancer of the plasma cells - a kind of white blood cell): 6 people, 50.00%
Insomnia (sleeplessness): 4 people, 33.33%
Constipation: 4 people, 33.33%
Depression: 4 people, 33.33%
Gastritis (inflammation of stomach): 4 people, 33.33%
Prostate Cancer: 4 people, 33.33%

* Approximation only. Some reports may have incomplete information.

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