Augmentin and Pennsaid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Augmentin (amoxicillin; clavulanate potassium) and Pennsaid (diclofenac sodium). Common drug interactions include chronic kidney disease among females and haematoma among males.

The phase IV clinical study analyzes what interactions people have when they take Augmentin and Pennsaid. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

What is Pennsaid?

Pennsaid has active ingredients of diclofenac sodium. eHealthMe is studying from 2,849 Pennsaid users. Check the latest studies of Pennsaid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

15 people who take Augmentin and Pennsaid together, and have interactions are studied.

Augmentin and Pennsaid drug interactions.

What are the common drug interactions of Augmentin and Pennsaid, by gender? *:

female:

Chronic kidney disease
Gastric ulcer (stomach ulcer)
Renal failure (kidney dysfunction)
Suicidal ideation
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Acute left ventricular failure (heart attack)
Acute respiratory failure
Renal injury (kidney injury)
Pain
Rash

male:

Haematoma (collection of blood outside the blood vessels)
Vascular pseudoaneurysm (leakage of arterial blood from an artery into the surrounding tissue with a continuing communication between the originating artery and the resultant adjacent cavity)
Renal injury (kidney injury)
Somnambulism (sleep walking)
Fatigue (feeling of tiredness)
Renal failure (kidney dysfunction)
Arthralgia (joint pain)
Chronic kidney disease
Confusional state
Dehydration (dryness resulting from the removal of water)

What are the common drug interactions of Augmentin and Pennsaid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Haematoma (collection of blood outside the blood vessels)
Vascular pseudoaneurysm (leakage of arterial blood from an artery into the surrounding tissue with a continuing communication between the originating artery and the resultant adjacent cavity)

50-59:

Chronic kidney disease
Gastric ulcer (stomach ulcer)
Renal failure (kidney dysfunction)
Suicidal ideation
Renal injury (kidney injury)

60+:

Chronic kidney disease
Pain
Rash
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 46.67%
High Blood Cholesterol: 6 people, 40.00%
Rashes (redness): 6 people, 40.00%
Pain: 6 people, 40.00%
Itching: 6 people, 40.00%
High Blood Pressure: 6 people, 40.00%
Stable Angina (a constant chest pain): 5 people, 33.33%
Hypersensitivity: 5 people, 33.33%
Gastric Ulcer (stomach ulcer): 5 people, 33.33%
Indigestion: 5 people, 33.33%

* Approximation only. Some reports may have incomplete information.

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