Augmentin and Sudafed 12 hour drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Augmentin (amoxicillin; clavulanate potassium) and Sudafed 12 hour (pseudoephedrine hydrochloride). Common drug interactions include fatigue among females and drug exposure during pregnancy among males.

The phase IV clinical study analyzes what interactions people have when they take Augmentin and Sudafed 12 hour. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

What is Sudafed 12 hour?

Sudafed 12 hour has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 4,687 Sudafed 12 hour users. Check the latest studies of Sudafed 12 hour.

On Aug, 02, 2026

96 people who take Augmentin and Sudafed 12 hour together, and have interactions are studied.

Augmentin and Sudafed 12 hour drug interactions.

What are the common drug interactions of Augmentin and Sudafed 12 Hour, by gender? *:

female:

Fatigue (feeling of tiredness)
Headache (pain in head)
Weight decreased
Pain in jaw
Pyrexia (fever)
Swelling
Cellulitis (infection under the skin)
Escherichia infection (bacterial infection by escherichia coli)
Appendicitis (inflammation of the appendix)
Aptyalism (deficiency or absence of saliva)

male:

Drug exposure during pregnancy
Respiratory distress (difficulty in breathing)
Renal failure (kidney dysfunction)
Apgar score low
Blood bilirubin increased
Hepatic steatosis (fatty liver disease)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Nausea (feeling of having an urge to vomit)
Neonatal disorder (disease of neonates)
Abdominal pain upper

What are the common drug interactions of Augmentin and Sudafed 12 Hour, by age (0-1 to 60+)? *:

0-1:

Apgar score low
Hydrocephalus (water on the brain)
Cardiovascular disorder (heart diseases)
Cerebral haemorrhage neonatal (bleeding in brain of baby of less than 1 month age)
Foetal disorder (fetus disease)
Haemorrhage intracranial (bleeding within the skull)
Neonatal disorder (disease of neonates)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Pregnancy with intrauterine device

2-9:

Arrhythmia (irregular heartbeat)
Sudden death
Unresponsive to stimuli
Vomiting

10-19:

Abdominal pain
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea
Emotional distress
Frustration (a form of poorly expressed anger)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Malaise (a feeling of general discomfort or uneasiness)
Procedural nausea
Procedural pain

20-29:

Dyspepsia (indigestion)
Hypersensitivity
Swelling
Upper respiratory tract infection
Chills (felling of cold)
Dysuria (painful or difficult urination)
Heart rate increased
Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

30-39:

Pyelonephritis (inflammation of kidney caused by bacteria)
Asthma
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Depression
Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Inflammatory bowel disease
Malignant melanoma (skin cancer rises from melancytes)
Renal failure acute (rapid kidney dysfunction)
Uveitis (inflammation of the uvea)
Headache (pain in head)

40-49:

Asthenia (weakness)
Headache (pain in head)
Abdominal pain upper
Anxiety
Asthma
Atrophic vulvovaginitis (inflammation of the vulva)
Back pain
Blood albumin decreased
Blood bilirubin increased
Blood chloride decreased

50-59:

Asthma
Bone erosion
Bone fragmentation
Bone pain
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Cellulitis (infection under the skin)
Colitis ulcerative (inflammation of colon with ulcer)
Dental caries
Enteritis (inflammation of the small intestine)
Enterococcal infection

60+:

Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Headache (pain in head)
Hyperglycaemia (high blood sugar)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Neck pain
Pain

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 24 people, 25.00%
Osteoporosis (bones weak and more likely to break): 24 people, 25.00%
Depression: 23 people, 23.96%
Upper Respiratory Tract Infection: 12 people, 12.50%
Thrombocytopenia (decrease of platelets in blood): 11 people, 11.46%
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 11 people, 11.46%
Osteomyelitis (infection of bone): 11 people, 11.46%
Menopause (end of monthly cycles in women): 11 people, 11.46%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 11 people, 11.46%
Anaemia (lack of blood): 11 people, 11.46%

* Approximation only. Some reports may have incomplete information.

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