Augmentin and Valproate sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Augmentin (amoxicillin; clavulanate potassium) and Valproate sodium (valproate sodium). Common drug interactions include acidosis among females and umbilical hernia among males.

The phase IV clinical study analyzes what interactions people have when they take Augmentin and Valproate sodium. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

What is Valproate sodium?

Valproate sodium has active ingredients of valproate sodium. It is often used in epilepsy. eHealthMe is studying from 24,044 Valproate sodium users. Check the latest studies of Valproate sodium.

On Jul, 12, 2026

51 people who take Augmentin and Valproate sodium together, and have interactions are studied.

Augmentin and Valproate sodium drug interactions.

What are the common drug interactions of Augmentin and Valproate Sodium, by gender? *:

female:

Acidosis (build-up of carbon dioxide in the blood)
Blood pressure decreased
Depressed level of consciousness
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Haemolytic anaemia (anaemia due to haemolysis)
Neutropenia (an abnormally low number of neutrophils)
Oxygen saturation decreased
Pancreatitis acute (sudden inflammation of pancreas)
Pyrexia (fever)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

male:

Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Dysphagia (a condition in which swallowing is difficult or painful)
Coagulation factor decreased (less clotting substance in blood)
Drug level decreased
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Vitamin k deficiency
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

What are the common drug interactions of Augmentin and Valproate Sodium, by age (0-1 to 60+)? *:

0-1:

Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back pain
Bone density decreased
Breast cancer
Calcium deficiency (lack of calcium)
Chest pain
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gastric haemorrhage (bleeding stomach)

2-9:

Coagulation factor decreased (less clotting substance in blood)
Drug level decreased
Vitamin k deficiency
Abdominal pain
Pancreatitis acute (sudden inflammation of pancreas)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Haematoma (collection of blood outside the blood vessels)
Acute hepatic failure
Anaemia macrocytic (a macrocytic class of anaemia)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)

10-19:

Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Dysphagia (a condition in which swallowing is difficult or painful)
Rhinovirus infection
Staphylococcal infection (an infection with staphylococcus bacteria)
Toothache (tooth pain)

20-29:

Acidosis (build-up of carbon dioxide in the blood)
Blood pressure decreased
Depressed level of consciousness
Overdose
Oxygen saturation decreased
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Lymphadenopathy (disease or enlargement of lymph nodes)
Rash

30-39:

Blood alkaline phosphatase increased
Blood bilirubin increased
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Gamma-glutamyltransferase increased

40-49:

Impaired self-care
Judgement impaired
Monocyte count decreased
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Polydipsia psychogenic (excessive water-drinking in the absence of a physiologic stimulus to drink)
Poor quality sleep
Rash pruritic (redness with itching)
Sedation
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

50-59:

C-reactive protein increased
Cardiac arrest
Haemophilus infection (bacterial infection by haemophilus influenzae)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Respiratory tract infection
Nausea (feeling of having an urge to vomit)
Vomiting
Pyrexia (fever)
Altered state of consciousness (altered state of mind)
Balance disorder

60+:

Pancreatitis (inflammation of pancreas)
Anaemia (lack of blood)
Haemolytic anaemia (anaemia due to haemolysis)
Hepatocellular injury (liver injury)
Abdominal pain
Anaemia haemolytic autoimmune (a condition in which the immune system attacks the red blood cells, resulting in fewer of these oxygen-transporting cells)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Cardiac failure
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Circulatory collapse

What are the existing conditions these people have? *

Pain: 14 people, 27.45%
Infection: 11 people, 21.57%
Anaemia (lack of blood): 7 people, 13.73%
Cardiac Failure: 7 people, 13.73%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 11.76%
Parkinson's Disease: 6 people, 11.76%
Lung Disorder (lung disease): 6 people, 11.76%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 9.80%
Sleep Disorder: 5 people, 9.80%
High Blood Pressure: 5 people, 9.80%

* Approximation only. Some reports may have incomplete information.

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