Augmentin and Vantin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Augmentin (amoxicillin; clavulanate potassium) and Vantin (cefpodoxime proxetil). Common drug interactions include chest pain among females and diabetes mellitus inadequate control among males.

The phase IV clinical study analyzes what interactions people have when they take Augmentin and Vantin. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

What is Vantin?

Vantin has active ingredients of cefpodoxime proxetil. It is often used in sinusitis. eHealthMe is studying from 788 Vantin users. Check the latest studies of Vantin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

44 people who take Augmentin and Vantin together, and have interactions are studied.

What are the common drug interactions of Augmentin and Vantin, by gender? *:

female:

Chest pain
Dyspnoea paroxysmal nocturnal (respiratory distress that awakens patients from sleep)
Hypertension (high blood pressure)
Mitral valve prolapse (heart's mitral valve doesn't work well)
Orthopnoea (shortness of breath (dyspnea) when lying down)
Palpitations (feelings or sensations that your heart is pounding or racing)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Vision blurred
Asthma
Chest discomfort

male:

Diabetes mellitus inadequate control
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Cellulitis (infection under the skin)
Cough
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
Pyrexia (fever)
Upper respiratory tract infection
Adenoidal disorder (pharyngeal tonsil disorder)

What are the common drug interactions of Augmentin and Vantin, by age (0-1 to 60+)? *:

0-1:

Adenoidal disorder (pharyngeal tonsil disorder)
Arrhythmia (irregular heartbeat)
Asthma
Chronic tonsillitis (long lasting inflammation of tonsil)
Cough
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Drooling (drop saliva uncontrollably from the mouth)
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

2-9:

Pyrexia (fever)
Arthralgia (joint pain)
Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac murmur (an heart sound in valve abnormality)
Cellulitis (infection under the skin)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Cough
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Diarrhoea

10-19:

n/a

20-29:

n/a

30-39:

Asthma
Weakness
Autoimmune hepatitis
Hepatitis (inflammation of the liver)
Hepatomegaly (abnormal enlargement of the liver)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Urine discolouration
Vomiting
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)

40-49:

Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
Pemphigoid (tense blisters on the skin)

50-59:

Hepatic atrophy (liver is decreased in size)
Hepatic failure (liver failure)
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Hepatic steatosis (fatty liver disease)
Hepatitis b
Injection site abscess
Liver transplant
Liver transplant rejection (failure of liver transplant)
Metastasis (spreadable cancer to other organ from origin)
Ovarian epithelial cancer (cancer that begins in the cells on the surface of the ovary)

60+:

Pain
Anxiety
Dyspnoea paroxysmal nocturnal (respiratory distress that awakens patients from sleep)
Hypertension (high blood pressure)
Mitral valve prolapse (heart's mitral valve doesn't work well)
Orthopnoea (shortness of breath (dyspnea) when lying down)
Palpitations (feelings or sensations that your heart is pounding or racing)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Vaginal haemorrhage (vaginal bleeding)
Vision blurred

What are the existing conditions these people have? *

Hypersensitivity: 12 people, 27.27%
Depression: 11 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 22.73%
Urinary Tract Infection: 7 people, 15.91%
Pain: 7 people, 15.91%
Kidney Infection (Pyelonephritis): 5 people, 11.36%
Diabetes: 5 people, 11.36%
Diabetes Mellitus Inadequate Control: 4 people, 9.09%
Diabetic Nephropathy (diabetic kidney disease): 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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