Augmentin and Xiidra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Augmentin (amoxicillin; clavulanate potassium) and Xiidra (lifitegrast). Common drug interactions include pneumonia among females and arthritis among males.

The phase IV clinical study analyzes what interactions people have when they take Augmentin and Xiidra. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

What is Xiidra?

Xiidra has active ingredients of lifitegrast. eHealthMe is studying from 15,244 Xiidra users. Check the latest studies of Xiidra.

On Aug, 04, 2026

16 people who take Augmentin and Xiidra together, and have interactions are studied.

What are the common drug interactions of Augmentin and Xiidra, by gender? *:

female:

Pneumonia
Depressed mood
Migraine (headache)
Muscle spasms (muscle contraction)
Respiratory disorder (respiratory disease)
Vomiting
Eye irritation
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Abdominal discomfort

male:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Drug ineffective
Neoplasm malignant (cancer tumour)
Scar

What are the common drug interactions of Augmentin and Xiidra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal discomfort
Fatigue (feeling of tiredness)
Pyrexia (fever)
Surgery
Tooth extraction
Abscess limb (limb infection)
Anal abscess
Aptyalism (deficiency or absence of saliva)
Cellulitis (infection under the skin)
Depression

50-59:

Depressed mood
Eye infection
Headache (pain in head)
Hereditary angioedema (recurrent episodes of severe swelling)
Malaise (a feeling of general discomfort or uneasiness)
Migraine (headache)
Muscle spasms (muscle contraction)
Pneumonia
Respiratory disorder (respiratory disease)
Upper respiratory tract infection

60+:

Eye irritation
Abnormal sensation in eye
Lacrimation increased
Nausea (feeling of having an urge to vomit)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Stomatitis (inflammation of mucous membrane of mouth)
Tongue ulceration (ulcers on tongue)
Vision blurred
Aphonia (inability to produce voice)
Cough

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 6 people, 37.50%
Immune System Disorder: 6 people, 37.50%
Hereditary Angioedema (recurrent episodes of severe swelling): 5 people, 31.25%
Dry Eyes (lack of adequate tears): 2 people, 12.50%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 2 people, 12.50%
Raynaud's Phenomenon (discoloration of the fingers, toes, and occasionally other areas): 2 people, 12.50%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 2 people, 12.50%
Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 2 people, 12.50%
Weight Decreased: 1 person, 6.25%
Back Pain: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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