Augmentin and Zoladex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Augmentin (amoxicillin; clavulanate potassium) and Zoladex (goserelin acetate). Common drug interactions include hypotension among females and osteonecrosis of jaw among males.

The phase IV clinical study analyzes what interactions people have when they take Augmentin and Zoladex. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

What is Zoladex?

Zoladex has active ingredients of goserelin acetate. It is often used in prostate cancer. eHealthMe is studying from 13,870 Zoladex users. Check the latest studies of Zoladex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

78 people who take Augmentin and Zoladex together, and have interactions are studied.

Augmentin and Zoladex drug interactions.

What are the common drug interactions of Augmentin and Zoladex, by gender? *:

female:

Hypotension (abnormally low blood pressure)
Fall
Osteonecrosis of jaw (death of bone of jaw)
Intervertebral disc degeneration (spinal disc degeneration)
Anxiety
Arthralgia (joint pain)
Dehydration (dryness resulting from the removal of water)
Hot flush (sudden feelings of heat)
Osteomyelitis (infection of bone)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

male:

Osteonecrosis of jaw (death of bone of jaw)
Anaemia (lack of blood)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Confusional state
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Headache (pain in head)
Rib fracture
Bone disorder
Bone pain
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Augmentin and Zoladex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Pain
Back pain
Fall
Hypotension (abnormally low blood pressure)
Intervertebral disc degeneration (spinal disc degeneration)
Anxiety
Osteonecrosis of jaw (death of bone of jaw)
Vertigo
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)

50-59:

Back pain
Bone disorder
Bone pain
Compression fracture (fracture due to pressure caused by injury)
Constipation
Deformity (disfigurement)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Erectile dysfunction
Erythema (redness of the skin)
Haematochezia (passage of stools containing blood)

60+:

Anaemia (lack of blood)
Pain
Depression
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Facial pain
Migraine (headache)
Osteomyelitis (infection of bone)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Rib fracture
Weight decreased

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 33 people, 42.31%
Depression: 22 people, 28.21%
High Blood Pressure: 21 people, 26.92%
Diabetes: 20 people, 25.64%
Breast Cancer: 19 people, 24.36%
Bone Pain: 19 people, 24.36%
Pain: 16 people, 20.51%
Breast Cancer Metastatic: 8 people, 10.26%
Nausea (feeling of having an urge to vomit): 4 people, 5.13%
Insomnia (sleeplessness): 4 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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