Avalide and Dyazide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avalide (hydrochlorothiazide; irbesartan) and Dyazide (hydrochlorothiazide; triamterene). Common drug interactions include thrombocytopenia among females and activated partial thromboplastin time prolonged among males.

The phase IV clinical study analyzes what interactions people have when they take Avalide and Dyazide. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.

What is Dyazide?

Dyazide has active ingredients of hydrochlorothiazide; triamterene. It is often used in high blood pressure. eHealthMe is studying from 11,506 Dyazide users. Check the latest studies of Dyazide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

20 people who take Avalide and Dyazide together, and have interactions are studied.

What are the common drug interactions of Avalide and Dyazide, by gender? *:

female:

Thrombocytopenia (decrease of platelets in blood)
Total lung capacity decreased
Hepatic lesion
Hepatic mass
Hepatic steatosis (fatty liver disease)
Lymphadenopathy (disease or enlargement of lymph nodes)
Metastases to central nervous system (cancer spreads to central nervous system)
Metastases to lung (cancer spreads to lung)
Osteolysis (dissolution of bone)
Acne (skin problems that cause pimples)

male:

Activated partial thromboplastin time prolonged
Albumin globulin ratio decreased
Brain natriuretic peptide decreased
C-reactive protein decreased
Cardiac disorder
Cardioactive drug level decreased
Chest pain
Confusional state
Depression
Diarrhoea

What are the common drug interactions of Avalide and Dyazide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hepatic lesion
Hepatic mass
Hepatic steatosis (fatty liver disease)
Lymphadenopathy (disease or enlargement of lymph nodes)
Metastases to central nervous system (cancer spreads to central nervous system)
Metastases to lung (cancer spreads to lung)
Osteolysis (dissolution of bone)
Acne (skin problems that cause pimples)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Gastric ulcer (stomach ulcer)

50-59:

Anaphylactic reaction (serious allergic reaction)
Burning sensation
Muscle spasms (muscle contraction)
Pain in extremity
Pruritus (severe itching of the skin)
Skin disorder (skin disease)

60+:

Blood urine
Cough
Drug effect decreased
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Feeling cold
Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)
Headache (pain in head)
Hyperaesthesia
Liver disorder (liver diseases)

What are the existing conditions these people have? *

Pain: 6 people, 30.00%
Breast Cancer Metastatic: 5 people, 25.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 15.00%
Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 3 people, 15.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 15.00%
Diabetes: 2 people, 10.00%
Cardiac Failure Congestive: 2 people, 10.00%
Type 2 Diabetes: 1 person, 5.00%
Neuropathy Peripheral (surface nerve damage): 1 person, 5.00%
Ill-Defined Disorder: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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