Avalide and Lactulose drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avalide (hydrochlorothiazide; irbesartan) and Lactulose (lactulose). Common drug interactions include hepatic failure among females and cough among males.

The phase IV clinical study analyzes what interactions people have when they take Avalide and Lactulose. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.

What is Lactulose?

Lactulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 46,960 Lactulose users. Check the latest studies of Lactulose.

On Jul, 17, 2026

26 people who take Avalide and Lactulose together, and have interactions are studied.

Avalide and Lactulose drug interactions.

What are the common drug interactions of Avalide and Lactulose, by gender? *:

female:

Hepatic failure (liver failure)
Lung neoplasm (tumour of lung)
Lymphadenopathy mediastinal (an enlargement of the lymph nodes in the part of the chest that separates the lungs)
Device related infection
Chronic kidney disease
Dental fistula
Cyst (a closed sac)
Bacterial test positive
Bone density decreased
Bone disorder

male:

Cough
Decreased appetite
Abdominal distension
Anaemia (lack of blood)
Death
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dementia (madness)
Dysphonia (speech disorder attributable to a disorder of phonation)
Febrile neutropenia (fever with reduced white blood cells)
Flatulence (flatus expelled through the anus)

What are the common drug interactions of Avalide and Lactulose, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Petechiae (a small red or purple spot caused by bleeding into the skin)
Rectal haemorrhage (bleeding from anus)
Renal cancer (cancer of kidney)
Back pain
Cerumen impaction
Deafness neurosensory
Oedema peripheral (superficial swelling)
Osteonecrosis of jaw (death of bone of jaw)
Pain
Renal failure (kidney dysfunction)

50-59:

Death
Hepatic failure (liver failure)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cyst (a closed sac)
Dementia (madness)
Dysphonia (speech disorder attributable to a disorder of phonation)
Hysterectomy
Intervertebral disc protrusion (spinal disc protrusion)
Neoplasm (tumour)

60+:

Chronic kidney disease
Blood osmolarity decreased
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Death
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Febrile neutropenia (fever with reduced white blood cells)
Flatulence (flatus expelled through the anus)
Gastric ulcer (stomach ulcer)

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 9 people, 34.62%
Breast Cancer: 9 people, 34.62%
Breast Cancer Metastatic: 9 people, 34.62%
Pain: 8 people, 30.77%
Infection: 6 people, 23.08%
High Blood Cholesterol: 6 people, 23.08%
Depression: 6 people, 23.08%
Fluid Retention (an abnormal accumulation of fluid in the blood): 5 people, 19.23%
Inflammation: 5 people, 19.23%
Stress And Anxiety: 5 people, 19.23%

* Approximation only. Some reports may have incomplete information.

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