Avalide and Loraz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avalide (hydrochlorothiazide; irbesartan) and Loraz (lorazepam). Common drug interactions include pain among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Avalide and Loraz. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.

What is Loraz?

Loraz has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,695 Loraz users. Check the latest studies of Loraz.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

84 people who take Avalide and Loraz together, and have interactions are studied.

What are the common drug interactions of Avalide and Loraz, by gender? *:

female:

Pain
Pulmonary oedema (fluid accumulation in the lungs)
Vomiting
Fall
Fatigue (feeling of tiredness)
Hyperlipidaemia (presence of excess lipids in the blood)
Abdominal pain
Asthenia (weakness)
Cardiac failure congestive
Chest discomfort

male:

Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat)
Extrasystoles
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
General physical health deterioration (weak health status)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)

What are the common drug interactions of Avalide and Loraz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Nephropathy (damage to or disease of a kidney)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

40-49:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Abdominal distension
Chest pain
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Pain in extremity
Abdominal discomfort
Anaemia (lack of blood)
Arthralgia (joint pain)
Asthenia (weakness)

50-59:

Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Atrioventricular block complete (heart block complete)
Chest pain
Chronic kidney disease
Coronary artery stenosis (narrowing of coronary artery)
Cough
Gastroenteritis (inflammation of stomach and intestine)
Hyperkalaemia (damage to or disease of the kidney)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Platelet count decreased

60+:

Chronic kidney disease
Fall
Death
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Erectile dysfunction
Heat exhaustion (dizziness and nausea and weakness caused by depletion of body fluids and electrolytes)
Joint swelling
Localised infection (infection at the single location)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 14.29%
Pain: 11 people, 13.10%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 13.10%
Depression: 10 people, 11.90%
Muscle Spasms (muscle contraction): 9 people, 10.71%
High Blood Cholesterol: 7 people, 8.33%
Infection: 7 people, 8.33%
Diabetes: 7 people, 8.33%
Fluid Retention (an abnormal accumulation of fluid in the blood): 7 people, 8.33%
Hypersensitivity: 7 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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