Avalide and Phenergan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avalide (hydrochlorothiazide; irbesartan) and Phenergan (promethazine hydrochloride). Common drug interactions include pleural effusion among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Avalide and Phenergan. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

On Aug, 05, 2026

61 people who take Avalide and Phenergan together, and have interactions are studied.

Avalide and Phenergan drug interactions.

What are the common drug interactions of Avalide and Phenergan, by gender? *:

female:

Pleural effusion (water on the lungs)
Arthralgia (joint pain)
Fall
Blood alkaline phosphatase increased
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Productive cough
Back pain
Decreased appetite
Metastases to bone (cancer spreads to bone)
Osteonecrosis of jaw (death of bone of jaw)

male:

Dehydration (dryness resulting from the removal of water)
Fall
Hemiparesis (weakness on one side of the body)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypokalaemia (low potassium)
Lethargy (tiredness)
Oral intake reduced
Pneumonia
Activities of daily living impaired
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)

What are the common drug interactions of Avalide and Phenergan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anaemia (lack of blood)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Aortic valve incompetence
Asthenia (weakness)
Asthma
Bronchitis acute (acute inflammation of the mucous membrane in the bronchial tubes)
Chest pain
Decreased appetite
Depression

40-49:

Anxiety
Pain in extremity
General physical health deterioration (weak health status)
Pain
Diarrhoea
Headache (pain in head)
Rash
Sinusitis (inflammation of sinus)
Abdominal discomfort
Anaemia (lack of blood)

50-59:

Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Neck pain
Oesophageal candidiasis (fungal infection of oesophagus)
Oesophageal stenosis (narrowing of oesophagus)
Oral candidiasis (fungal infection of mouth)
Osteoporosis (bones weak and more likely to break)
Pericardial effusion (fluid around the heart)
Productive cough
Pulmonary hypertension (increase in blood pressure in the lung artery)
Rhinitis allergic (inflammation of the nasal airways due to allergy)

60+:

Pyrexia (fever)
Dehydration (dryness resulting from the removal of water)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Cardiovascular disorder (heart diseases)
Death
Decreased activity
Depressed level of consciousness
Drug toxicity

What are the existing conditions these people have? *

Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 11 people, 18.03%
Pain: 8 people, 13.11%
Breast Cancer Metastatic: 7 people, 11.48%

* Approximation only. Some reports may have incomplete information.

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