Avandamet and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avandamet (metformin hydrochloride; rosiglitazone maleate) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include muscle spasms among females and chorea among males.

The phase IV clinical study analyzes what interactions people have when they take Avandamet and Hydroxyzine. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Avandamet?

Avandamet has active ingredients of metformin hydrochloride; rosiglitazone maleate. It is often used in diabetes. eHealthMe is studying from 16,084 Avandamet users. Check the latest studies of Avandamet.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,070 Hydroxyzine users. Check the latest studies of Hydroxyzine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

25 people who take Avandamet and Hydroxyzine together, and have interactions are studied.

Avandamet and Hydroxyzine drug interactions.

What are the common drug interactions of Avandamet and Hydroxyzine, by gender? *:

female:

Muscle spasms (muscle contraction)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Palpitations (feelings or sensations that your heart is pounding or racing)
Blood glucose increased
Hypoaesthesia (reduced sense of touch or sensation)
Pain
Pneumonia
Arthralgia (joint pain)
Asthenia (weakness)
Back pain

male:

Chorea (abnormal involuntary movement disorder)
Chronic kidney disease
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Tardive dyskinesia (a disorder that involves involuntary movements)
Tremor (trembling or shaking movements in one or more parts of your body)
Dyskinesia (abnormality or impairment of voluntary movement)
Emotional disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Family stress

What are the common drug interactions of Avandamet and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chorea (abnormal involuntary movement disorder)
Diabetes mellitus inadequate control
Dyskinesia (abnormality or impairment of voluntary movement)
Emotional disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Family stress
Headache (pain in head)
Hyperglycaemia (high blood sugar)
Injury
Insulin-requiring type 2 diabetes mellitus

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Diabetic coma
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hyperkalaemia (damage to or disease of the kidney)
Renal tubular necrosis (death of kidney tubules)

50-59:

Asthenia (weakness)
Back pain
Blood glucose decreased
Blood glucose increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiomegaly (increased size of heart than normal)
Chest discomfort
Chest pain
Coronary artery restenosis (recurrence of narrowing of artery)
Cough

60+:

Blood glucose increased
Adrenal disorder
Atelectasis (partial or complete collapse of the lung)
Back pain
Blood alkaline phosphatase increased
Blood sodium decreased
Bone fragmentation
Cardiomegaly (increased size of heart than normal)
Constipation
Cough

What are the existing conditions these people have? *

Type 2 Diabetes: 6 people, 24.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 24.00%
Pain: 5 people, 20.00%
Depression: 5 people, 20.00%
High Blood Cholesterol: 4 people, 16.00%
Cough: 4 people, 16.00%
Breast Cancer: 4 people, 16.00%
Urinary Retention (the inability to completely or partially empty the bladder): 3 people, 12.00%
Muscle Spasms (muscle contraction): 3 people, 12.00%
Irritable Bowel Syndrome: 3 people, 12.00%

* Approximation only. Some reports may have incomplete information.

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