Avandamet and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avandamet (metformin hydrochloride; rosiglitazone maleate) and Melatonin (melatonin). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Avandamet and Melatonin. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Avandamet?

Avandamet has active ingredients of metformin hydrochloride; rosiglitazone maleate. It is often used in diabetes. eHealthMe is studying from 16,084 Avandamet users. Check the latest studies of Avandamet.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,213 Melatonin users. Check the latest studies of Melatonin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

11 people who take Avandamet and Melatonin together, and have interactions are studied.

Avandamet and Melatonin drug interactions.

What are the common drug interactions of Avandamet and Melatonin, by gender? *:

female:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

male:

Chronic kidney disease
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Nephrogenic anaemia (anaemia due to kidney disease)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Death
Headache (pain in head)
Hypertension (high blood pressure)
Intracranial aneurysm (bulging, weak area in the wall of a cranial artery)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)

What are the common drug interactions of Avandamet and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Headache (pain in head)
Hypertension (high blood pressure)
Intracranial aneurysm (bulging, weak area in the wall of a cranial artery)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Pain
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Blood glucose increased

60+:

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Ear infection
Renal failure (kidney dysfunction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Nephrolithiasis (calculi in the kidneys)
Stomatitis (inflammation of mucous membrane of mouth)
Urinary tract infection
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 54.55%
Pain: 5 people, 45.45%
Cardiac Disorder: 5 people, 45.45%
High Blood Pressure: 4 people, 36.36%
Gastric Ulcer (stomach ulcer): 3 people, 27.27%
Nausea (feeling of having an urge to vomit): 3 people, 27.27%
Blood Pressure Abnormal: 3 people, 27.27%
Indigestion: 3 people, 27.27%
High Blood Cholesterol: 2 people, 18.18%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Avandamet and Melatonin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously