Avandaryl and Glucotrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avandaryl (glimepiride; rosiglitazone maleate) and Glucotrol (glipizide). Common drug interactions include hepatic steatosis among females and myocardial infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Avandaryl and Glucotrol. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Avandaryl?

Avandaryl has active ingredients of glimepiride; rosiglitazone maleate. It is often used in diabetes. eHealthMe is studying from 2,660 Avandaryl users. Check the latest studies of Avandaryl.

What is Glucotrol?

Glucotrol has active ingredients of glipizide. It is often used in diabetes. eHealthMe is studying from 20,322 Glucotrol users. Check the latest studies of Glucotrol.

On Jul, 18, 2026

68 people who take Avandaryl and Glucotrol together, and have interactions are studied.

Avandaryl and Glucotrol drug interactions.

What are the common drug interactions of Avandaryl and Glucotrol, by gender? *:

female:

Hepatic steatosis (fatty liver disease)
Humerus fracture (injury to the upper arm bone)
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Iliac artery stenosis (the abnormal narrowing of a iliac artery)
Implant site erythema (redness at implant site)
Injury
Intermittent claudication
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Lymphadenopathy mediastinal (an enlargement of the lymph nodes in the part of the chest that separates the lungs)

male:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Loss of consciousness
Nerve injury
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Hypertension (high blood pressure)
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Blood glucose increased
Cardiovascular disorder (heart diseases)

What are the common drug interactions of Avandaryl and Glucotrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Death
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

40-49:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Cardiac failure congestive
Hypertension (high blood pressure)
Activities of daily living impaired
Dyspnoea (difficult or laboured respiration)
Abdominal pain
Abdominal pain upper
Anaemia (lack of blood)
Anorectal discomfort
Arrhythmia (irregular heartbeat)

50-59:

Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Swelling
Thrombosis (formation of a blood clot inside a blood vessel)
Ventricular fibrillation (abnormally irregular heart rhythm)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Cardiac failure congestive
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Cardiac disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Arrhythmia (irregular heartbeat)

60+:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Blood glucose increased
Chest pain
Death
Ejection fraction decreased (systolic heart failure)
Erythema (redness of the skin)
Eye disorder
Hyperlipidaemia (presence of excess lipids in the blood)

What are the existing conditions these people have? *

Type 2 Diabetes: 10 people, 14.71%

* Approximation only. Some reports may have incomplete information.

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