Avandaryl and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avandaryl (glimepiride; rosiglitazone maleate) and Zide (hydrochlorothiazide). Common drug interactions include fluid retention among females and cerebrovascular accident among males.

The phase IV clinical study analyzes what interactions people have when they take Avandaryl and Zide. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Avandaryl?

Avandaryl has active ingredients of glimepiride; rosiglitazone maleate. It is often used in diabetes. eHealthMe is studying from 2,660 Avandaryl users. Check the latest studies of Avandaryl.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

On Jul, 15, 2026

58 people who take Avandaryl and Zide together, and have interactions are studied.

What are the common drug interactions of Avandaryl and Zide, by gender? *:

female:

Fluid retention (an abnormal accumulation of fluid in the blood)
Gait disturbance
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Injury
Lacunar infarction (a type of stroke)
Lethargy (tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Muscular weakness (muscle weakness)
Oropharyngeal pain
Pharyngitis (inflammation of the pharynx, causing a sore throat)

male:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pruritus (severe itching of the skin)
Rectal haemorrhage (bleeding from anus)
Renal failure (kidney dysfunction)
Acute respiratory distress syndrome
Adverse drug reaction
Affective disorder (mental disorder)
Anaemia (lack of blood)
Anal haemorrhage

What are the common drug interactions of Avandaryl and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cardiac failure congestive
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pulmonary hypertension (increase in blood pressure in the lung artery)

40-49:

Abdominal pain
Chest pain
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Neck pain
Oropharyngeal pain
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Road traffic accident
Tenderness (pain or discomfort when an affected area is touched)
Tension headache

50-59:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cerumen impaction
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Contusion (a type of hematoma of tissue in which capillaries)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

60+:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Malaise (a feeling of general discomfort or uneasiness)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Oedema peripheral (superficial swelling)
Respiratory failure (inadequate gas exchange by the respiratory system)
Swelling face
Weight increased
Alopecia (absence of hair from areas of the body)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)

What are the existing conditions these people have? *

High Blood Cholesterol: 5 people, 8.62%
Type 2 Diabetes: 4 people, 6.90%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 6.90%
Stress And Anxiety: 3 people, 5.17%
Neuralgia (pain in one or more nerves): 3 people, 5.17%
Insomnia (sleeplessness): 3 people, 5.17%

* Approximation only. Some reports may have incomplete information.

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