Avapro and Lomotil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avapro (irbesartan) and Lomotil (atropine sulfate; diphenoxylate hydrochloride). Common drug interactions include vomiting among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Avapro and Lomotil. It is created by eHealthMe based on reports of 79 people who take the same drugs from the FDA, and is updated regularly.

What is Avapro?

Avapro has active ingredients of irbesartan. It is often used in high blood pressure. eHealthMe is studying from 19,840 Avapro users. Check the latest studies of Avapro.

What is Lomotil?

Lomotil has active ingredients of atropine sulfate; diphenoxylate hydrochloride. It is often used in diarrhea. eHealthMe is studying from 19,184 Lomotil users. Check the latest studies of Lomotil.

On Jul, 19, 2026

79 people who take Avapro and Lomotil together, and have interactions are studied.

What are the common drug interactions of Avapro and Lomotil, by gender? *:

female:

Vomiting
Asthenia (weakness)
Headache (pain in head)
Rash
Abdominal pain
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Back pain
Cardiac murmur (an heart sound in valve abnormality)
Chest pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

male:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Pain in extremity
Pulmonary embolism (blockage of the main artery of the lung)
Arthralgia (joint pain)
Asthenia (weakness)
Insomnia (sleeplessness)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Mobility decreased (ability to move is reduced)

What are the common drug interactions of Avapro and Lomotil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Weight decreased

40-49:

Hyperbilirubinaemia (excess of bilirubin in the blood)
Abdominal discomfort
Antinuclear antibody positive
Colitis (inflammation of colon)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Dyspnoea (difficult or laboured respiration)
Generalised oedema (swelling all over the body)
Oliguria (not enough urine)
Thrombocytopenia (decrease of platelets in blood)

50-59:

Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Cough
Dyspnoea (difficult or laboured respiration)
Herpes simplex (herpes simplex is a common viral infection)
Iron deficiency anaemia

60+:

Nausea (feeling of having an urge to vomit)
Vomiting
Dry skin
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Mobility decreased (ability to move is reduced)
Oedema peripheral (superficial swelling)
Pain in extremity
Pruritus generalised (generalized itching)
Pulmonary embolism (blockage of the main artery of the lung)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 13.92%
Pain: 10 people, 12.66%
Nausea (feeling of having an urge to vomit): 8 people, 10.13%
High Blood Cholesterol: 8 people, 10.13%
Oropharyngeal Pain: 7 people, 8.86%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 5 people, 6.33%
Depression: 5 people, 6.33%
Neuropathy Peripheral (surface nerve damage): 5 people, 6.33%
Multiple Myeloma (cancer of the plasma cells): 5 people, 6.33%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 4 people, 5.06%

* Approximation only. Some reports may have incomplete information.

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