Avapro and Pamelor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avapro (irbesartan) and Pamelor (nortriptyline hydrochloride). Common drug interactions include hypercholesterolaemia among females and convulsions among males.

The phase IV clinical study analyzes what interactions people have when they take Avapro and Pamelor. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Avapro?

Avapro has active ingredients of irbesartan. It is often used in high blood pressure. eHealthMe is studying from 19,840 Avapro users. Check the latest studies of Avapro.

What is Pamelor?

Pamelor has active ingredients of nortriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 4,069 Pamelor users. Check the latest studies of Pamelor.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

13 people who take Avapro and Pamelor together, and have interactions are studied.

What are the common drug interactions of Avapro and Pamelor, by gender? *:

female:

Hypercholesterolaemia (high levels of cholesterol in the blood)
Hyperhidrosis (abnormally increased sweating)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Hypoacusis (loss of hearing)
Hypoglycaemic coma (coma due to deficiency of glucose in the bloodstream)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)
Intermittent claudication
Intervertebral disc degeneration (spinal disc degeneration)

male:

Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Anaemia (lack of blood)
Eye haemorrhage (bleeding in the eye)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematochezia (passage of stools containing blood)
Hyperkalaemia (damage to or disease of the kidney)
Hyperlipidaemia (presence of excess lipids in the blood)
Intervertebral disc protrusion (spinal disc protrusion)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)

What are the common drug interactions of Avapro and Pamelor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Vomiting

40-49:

n/a

50-59:

Benign prostatic hyperplasia (benign enlargement of the prostate)
Blood potassium increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dyspepsia (indigestion)
Eye haemorrhage (bleeding in the eye)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematochezia (passage of stools containing blood)
Hyperkalaemia (damage to or disease of the kidney)
Hyperlipidaemia (presence of excess lipids in the blood)

60+:

Loss of consciousness
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Balance disorder
Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)
Breast mass
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)

What are the existing conditions these people have? *

Stress And Anxiety: 1 person, 7.69%
Renal Mass (mass in kidney): 1 person, 7.69%
Renal Cyst (kidney cyst): 1 person, 7.69%
Renal Cell Carcinoma (a kidney cancer): 1 person, 7.69%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 1 person, 7.69%
Metastatic Neoplasm (spreadable cancer tumour): 1 person, 7.69%
Hepatic Lesion: 1 person, 7.69%
Flank Pain (a distressing sensation experienced around the lower back and the upper abdomen): 1 person, 7.69%
Dizziness: 1 person, 7.69%
Chest Pain: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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