Avastin and Cyramza drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avastin (bevacizumab) and Cyramza (ramucirumab). Common drug interactions include nephrotic syndrome among females and nephrotic syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Avastin and Cyramza. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Avastin?

Avastin has active ingredients of bevacizumab. It is often used in high blood cholesterol. eHealthMe is studying from 76,365 Avastin users. Check the latest studies of Avastin.

What is Cyramza?

Cyramza has active ingredients of ramucirumab. eHealthMe is studying from 4,052 Cyramza users. Check the latest studies of Cyramza.

On Jul, 14, 2026

28 people who take Avastin and Cyramza together, and have interactions are studied.

What are the common drug interactions of Avastin and Cyramza, by gender? *:

female:

Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Anaemia (lack of blood)
Oedema peripheral (superficial swelling)
Pain
Hair colour changes
Hair disorder
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Arthralgia (joint pain)
Fatigue (feeling of tiredness)

male:

Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Proteinuria (presence of protein in the urine)
Colon cancer
Gastric cancer (stomach cancer)
Gastric perforation (hole in stomach)
Rectal haemorrhage (bleeding from anus)

What are the common drug interactions of Avastin and Cyramza, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Intestinal perforation (complete penetration of the wall of the intestine)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Pneumonia
Pyrexia (fever)
Thrombosis (formation of a blood clot inside a blood vessel)

40-49:

Red blood cell count decreased
White blood cell count decreased

50-59:

Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Alopecia (absence of hair from areas of the body)
Hypertensive crisis
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Colon cancer
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Eosinophil count increased
Gastrointestinal perforation (hole in the digestive tract)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Rectal haemorrhage (bleeding from anus)

60+:

Diaphragmatic rupture (diaphragmatic injury)
Proteinuria (presence of protein in the urine)
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Neutropenia (an abnormally low number of neutrophils)
Pain
Cardiac failure
Cardiac failure congestive
Gastric cancer (stomach cancer)
Gastric perforation (hole in stomach)

What are the existing conditions these people have? *

Colon Cancer: 10 people, 35.71%
Rectal Cancer (cancer of rectum): 6 people, 21.43%
High Blood Pressure: 5 people, 17.86%
Diarrhea: 3 people, 10.71%
Colon Cancer Stage Iv: 3 people, 10.71%
Pigmentation Disorder (disturbances of human skin colour): 2 people, 7.14%
Lung Cancer - Non-Small Cell (lung cancer): 2 people, 7.14%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 2 people, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.14%
Constipation: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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