Avinza and Zofran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avinza (morphine sulfate) and Zofran (ondansetron hydrochloride). Common drug interactions include multiple myeloma among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Avinza and Zofran. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Avinza?

Avinza has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 1,728 Avinza users. Check the latest studies of Avinza.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

On Jul, 29, 2026

33 people who take Avinza and Zofran together, and have interactions are studied.

What are the common drug interactions of Avinza and Zofran, by gender? *:

female:

Multiple myeloma (cancer of the plasma cells)
Neoplasm malignant (cancer tumour)
Osteoporosis (bones weak and more likely to break)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Sleep disorder
Small intestinal obstruction (blockage in small intestine)
Urinary tract infection
Weight increased
Pain in extremity
Acetabulum fracture (socket of the hip joint- fracture)

male:

Death
Abdominal hernia
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatitis b
Lung neoplasm malignant (cancer tumour of lung)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Malignant neoplasm progression (cancer tumour came back)
Post-traumatic stress disorder
Rash generalised (rash on most of body parts)
Schizoaffective disorder (a mental disorder characterized by disordered thought)

What are the common drug interactions of Avinza and Zofran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Abdominal distension
Abdominal neoplasm (cancer of the stomach)
Abscess jaw (tooth abscess or root abscess)
Acetabulum fracture (socket of the hip joint- fracture)
Actinomycosis (infection that causes sores, or abscesses)
Alopecia (absence of hair from areas of the body)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anorectal discomfort

30-39:

n/a

40-49:

Death
Drug effect decreased
Headache (pain in head)
Pain in extremity
Abdominal hernia
Abdominal pain
Acute febrile neutrophilic dermatosis (skin disease characterized by the sudden onset of fever, leukocytosis, and tender)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
Asthma

50-59:

Chest pain
Dehydration (dryness resulting from the removal of water)
Hypotension (abnormally low blood pressure)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Stress
Arthropathy
Depressed mood
Depression
Diarrhoea
Dyspnoea (difficult or laboured respiration)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Pneumonia
Renal impairment (severely reduced kidney function)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the existing conditions these people have? *

Stress And Anxiety: 7 people, 21.21%
Neuralgia (pain in one or more nerves): 6 people, 18.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 18.18%
Fluid Retention (an abnormal accumulation of fluid in the blood): 6 people, 18.18%
Depression: 6 people, 18.18%
Urinary Tract Infection: 5 people, 15.15%
Muscle Aches (muscle pain): 5 people, 15.15%
Blood Calcium Decreased: 5 people, 15.15%
Metastases To Bone (cancer spreads to bone): 4 people, 12.12%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 3 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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